BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Such a comprehensive review on m6A deposition and its effect on RNA-Protein interactions.

Congrats Joe!

so great!

Very precise method to quantify pseudouridine level developed by Chun-Xiao Song lab in Ludwig Oxford. biorxiv.org/content/10.110…

What are the forces shaping m6A evolution? Using interspecies hybrids in yeast and mammalian systems, we find that changes in m6A levels are nearly exclusively driven in cis. genomebiology.biomedcentral.com/articles/10.11…

very interesting study

Congratulations

Minipileup, a straightforward pileup-based multi-sample variant caller. Useful for data inspection or when mainstream callers are not applicable. Initially developed in 2012 as part of htsbox. Now released in a separate repo: github.com/lh3/minipileup

I submitted my Canadian tourist visa application in London Sep. 2023 for a conference talk in mid-Dec 2023. No visa arrived in time and missed all the opportunities. Even now (7 months later), still waiting for any update. Hoping for a long-term visa for 2025 and future events.

Congrats! Thrilled to see your independent work finally out.

An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles. sciencedirect.com/science/articl…

Our SpliceRUSH paper is officially out! If u have an RBP and would like to map its targets, u will think of CLIP. What if u have your favorite gene (e.g., a drug target) and want to map all the splicing-regulatory elements? SpliceRush is just for this! nature.com/articles/s4146…

Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new Royal Society Publishing biographical memoir: royalsocietypublishing.org/doi/10.1098/rs…

Congratulations to HHMI Investigator Howard Chang, who has been awarded the Foundation for the National Institutes of Health 2024 Lurie Prize in Biomedical Sciences for his work revealing the importance of long noncoding RNA in gene regulation & its impact on human disease: hhmi.news/3RdYsTp

Can’t wait to delve into this new book.

Congrats to our Head of department!

How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 nature.com/articles/s4159…