QUIZ(CONT) 86M presented complaining for generalised pruritus. He had evident erythrematous skin involvement and lymphadenopathy. CBC, morphology and lymphocyte counts are provided> Please comment the most relevant diagnostic feature in blood count and immunophenotype #hemepath

QUIZ(CONT) 86M presented complaining for generalised pruritus. He had evident erythrematous skin involvement and lymphadenopathy. CBC, morphology and lymphocyte counts are provided> Which diagnostic test do you prefer to assess this patient? #hemepath

QUIZ(final) 86 man presented with erythroderma and lymphocytes with cerebriform nuclei, which were as almost exclusively T4 lymphocytes, CD7-, CD27+ with selective expression Vβ 5.1. The above picture was compatible with #SEZARY syndrome verified by cutaneous biopsy #hemepath

QUIZ(NEW) 79F, Increase of WBC from 10000/μL to 98900/μL (CBC presented), in 3 months. Palpated extracurricular lymphadenopathy and splenomegaly (20cm length). No B symptoms. Flow cytometry showed 2.5% clonal B cells and an abnormal population CD45 negative CD3-CD4+. Vote next>

QUIZ(NEW) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly (20cm). Flow cytometry showed 2.5% clonal B cells and an abnormal population CD45 negative CD3-CD4+. What is your first diagnostic impression? #hemepath

QUIZ(cont) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly (20cm). Flow cytometry showed 2.5% clonal B cells and an abnormal population CD45 negative CD3-CD4+. What diagnostic evaluation you seek first? #hemepath

QUIZ(cont) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly (20cm). Flow cytometry showed 2.5% clonal B cells and an abnormal population CD45 negative CD3-CD4+. The immunophenotype of the atypic CD45 negative cells and B cells is presented >#hemepath

QUIZ(cont) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly (20cm). The immunophenotype of the atypic CD45 negative cells and B cells is presented > Do you wish to revote? #hemepath

QUIZ(cont) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly (20cm). Flow cytometry showed 2.5% clonal B cells and an abnormal population CD45 negative CD3-CD4+. FISH was performed. Speculate on the result derived >#hemepath

QUIZ(FINAL) 79F, Hyperleucocytosis, supraclavicular lymphadenopathy and splenomegaly CD45 negative CD3-CD4+. with TCL1+ and inv(14) Atypical phenotype T Prolymphocytic Leukaemia >#hemepath

QUIZ (NEW) 54M fever since one week. Anaemia and thrombocytopenia. Bone marrow with blasts 19%. Morphology, immunophenotype and dot plots are provided>next vote sessions #hemepath, #flowcytometry, #morphology

QUIZ (cont) 54M fever since one week. Anaemia and thrombocytopenia. Bone marrow with blasts 19%. Morphology interpretation. Which of the following morphologic characteristics helps in diagnosis #hemepath, #flowcytometry, #morphology

QUIZ (cont) 54M fever since one week. Anaemia and thrombocytopenia. Bone marrow with blasts 19%. Morphology interpretation. Which of the following immunophenotypic characteristics helps in diagnosis #hemepath, #flowcytometry, #morphology

QUIZ (cont) 54M fever since one week. Anaemia and thrombocytopenia. Bone marrow with blasts 19%. Morphology interpretation. Which cytogenetic abnormalities do you expect in this case? #hemepath, #flowcytometry, #morphology

QUIZ (FINAL) 54M ,BM with blasts 19%. Aberrant CD19+ and CD34+/CD56+ expression. t(8;21) translocation was suspected and verified by FISH. A diagnosis of AML with recurrent genetic abnormality t(8;21) even with blasts 19% was established #hemepath, #flowcytometry, #morphology

QUIZ(NEW) 18F with quinsy, fever and jaundice. Palpable cervical lymphadenopathy Anemia, leukocytosis and transaminasemia. Please vote in next tweets #hemepath, #morphology #flowcytometry

QUIZ(NEW) 18F with quinsy, fever and jaundice. Palpable cervical lymphadenopathy Anemia, leukocytosis and transaminasemia. Morphology is compatible with #hemepath, #morphology #flowcytometry

QUIZ(NEW) 18F with quinsy, fever and jaundice. Palpable cervical lymphadenopathy Anemia, leukocytosis and transaminasemia. Interpretation of CBC and flow cytometry counts #hemepath, #morphology #flowcytometry

QUIZ(NEW) 18F with quinsy, fever and jaundice. Palpable cervical lymphadenopathy Anemia, leukocytosis and transaminasemia. Interpretation of clinical settings, morphology and flow for a working diagnosis #hemepath, #morphology #flowcytometry

QUIZ(FINAL) 18F with quinsy, fever, jaundice, cervical lymphadenopathy, anemia, leukocytosis & transaminasemia. IgM+ for EBV. Selective expression of TCR Vb 13.2 in atypical T8 and T4 subpopulations in this case of Infectious Mononucleosis #hemepath, #morphology #flowcytometry