3.1 #cancer update "This innovative treatment protocol, comprising NUC-3373, Pembrolizumab, and leucovorin, represents a daring foray into uncharted territory—a realm where hope intertwines with uncertainty." #thankscancer . This is the phase 1 trials I will be on .

4 #cancer update Jim, sipping his pineapple soda with a furrowed brow, posed a poignant query, "How will this experimental regimen impact your well-being?" #thankscancer . Jim (friend and doctor and my wife in a pub discussing the trials .

5 #cancer update "With cautious optimism," I replied, "I embrace the unknown, trusting in the expertise of Professor Spicer and his team. #thankscancer . We still have Picc line to be inserted on Monday . Just waiting anxiously while the tumours grow !

5.1 #cancer update While the familiarity of NUC-3373 offers a semblance of reassurance, the addition of Pembrolizumab introduces an element of trepidation—anxiety mingled with anticipation." #thankscancer . It’s becoming overwhelming as I am racked in pain.

6 #cancer update Elaborating on the potential side effects, I delineated, "The usual , diarrhoea, fatigue (tiredness), nausea and vomiting, infusion reactions, anemia (a lack of red blood cells), #thankscancer

#cancer update 6.1 headaches, and loss of appetite,the spectrum of adverse reactions is vast and varied, underscoring the delicate balance between therapeutic efficacy and physiological compromise." #thankscancer . I have most of these symptoms without being on the trials .

7 #cancer update Inquisitive by nature, Jim sought to unravel the intricacies of Pembrolizumab's mechanism of action, #thankscancer . We are just in the house discussing the trials .

8 #cancer update I explained , prompting a scholarly discourse on the interplay between immunotherapy and tumor biology—an exchange laden with scientific jargon and profound insights. #thankscancer . Jim and discussing my anxieties of the treatment.

9 #cancer update “Pembrolizumab is a type of immunotherapy that stimulates the body's immune system to fight cancer cells. #thankscancer

9.1 cancer update : It targets and blocks a protein called PD-1 on the surface of certain immune cells called T cells. Blocking PD-1 triggers the T-cells to find and kill cancer cells. #thankscancer

10 #cancer update By blocking the protein PD1 of the T cells, the T cells can better recognize the cancer cells. In my case, the cancer cells have mutated 14 times, and the tumor cell , #thankscancer

10.1 #cancer update camouflage is beginning to unravel, making them a target for the T cells—the hunter-killer unit of the immune system—to seek and destroy the tumor cells. #thankscancer . The discussion with jim my friend the doctor continues and just eludes to more questions.

11 #cancer update It sounds good in theory; we have the combination of immunotherapy treatment getting an immune response with the chemotherapy NUC 3373. #thankscancer . The NUC 3373 is a modified version of 5FU used for solid tumours . New line of thinking !

11.1 #cancer update NUC 3373 They stop the cells from making and repairing DNA,which cancer cells need to grow and multiply,killing cancer cells but also affecting normal cells, which are similar to those cancer cells, without prejudice or discrimination.Nuke 'em!” #thankscancer

Rhod Gilbert: Doctor reveals how 'brutal' therapy tackled comedian's cancer bbc.co.uk/news/uk-wales-…

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I feel the writers of the #crown are better than me . My 50 k words are nearly done . I just need to finish. Add the sparkles perhaps ? It is time ! Or is it ? What happens beyond death in conquering death is also important ! My hands and arms feels twitchy!