Final announcement! #FragileNucleosome is honoured to be collaborating with the upcoming conference:𝐇𝐢𝐝𝐝𝐞𝐧 𝐂𝐞𝐥𝐥, 𝐃𝐚𝐫𝐤 𝐆𝐞𝐧𝐨𝐦𝐞. @chrstne.bsky.social , one of our organizers, will give a special lecture. Hope to see FN community there too! #hcdg25 tinyurl.com/37x72s67

Crack the code: Have you ever wondered whether the “histone code” is only present on histones? Is it exciting that a similar “code” embedded in non-histone proteins is also involved in gene regulation? Check out our new preprint on a “histone mimic code”: biorxiv.org/content/10.110…

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. nature.com/articles/s4146…

1/ I am beyond thrilled to share our new paper in Cell! We explored the regulatory principles underlying pleiotropy in psychiatric disorders. cell.com/cell/abstract/…

Transcription ahead of chromatin regulation? Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our collaborations with Wendy Bickmore and Robert Illingworth, who worked tirelessly to insure this data saw daylight!journals.plos.org/plosgenetics/a…

Shifting the pitch and contours of Waddington’s valleys, putative enhancers, and transcription through H3K27me3 chromatin in the endoderm. Find it all here: journals.plos.org/plosgenetics/a…. Fantastic collaboration with Josh Brickman and Wendy Bickmore. Well done Jurriaan and Dipta Sengupta.

CPGE's most recent publication on cohesin function and chromatin domain organization is out now in Science Advances. This thread will take a look at some of the key observations from the paper! #chromatin #epigenetics #genomics #northwestern #dna science.org/doi/10.1126/sc…

Happy to contribute to this excellent story about heterochromatin role in centromere maintenance, led by Ben Carty ! Heterochrom. boundaries control centromere expansion, drift & number! Great usage of induced neocentromere model and modern epigenomics across the labs🥳

Our new study shows in our that the fate of foreign DNA in a eukaryote depends on its GC content. It can either packaged into active or inactive chromatin. science.org/doi/10.1126/sc…

IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science The Night Science Podcast 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences

New paper alert! The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and DNA repair efficiency academic.oup.com/nar/article/53….

We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics DM me for inquiries pl apply/share tinyurl.com/m6jnksk5

Our latest preprint on emergent #3Dgenome reorganization from the stepwise assembly of the #transcriptional #condensates. Check it out! #GeneExpression #chromatin Gene Regulation Phase Transition Papers 4DNucleome #cellularstress tinyurl.com/3sdsdrd6

Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine: Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor genomemedicine.biomedcentral.com/articles/10.11…

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, Kazuhiro Maeshima, for supervision. Amazing collab with Rosana Collepardo’s group!" (1/n)

🚨 Registration for the Molecular Biosystems Conference is now OPEN! Join us to discuss cutting-edge research in gene regulation & functional genomics. 📅 Sep 29-Oct 3, 2025 📍 Puerto Varas, Chile 🔗 Register here: molbiosystems.com Register now—space is limited!

❤️‍🔥 Passionate about gene regulation research, wet/dry lab? 🎡 Excited about London's vibrant research and social scene? 🔬 Looking for a funded postdoc position (+ ideally, have the CV & drive to apply for a fellowship in your 1st year)? Please DM/email me to discuss!

I am so happy to see this work finally out 🎉 authors.elsevier.com/c/1kqIJ_Oylrlz… Thanks to all the authors for the incredible teamwork!!!

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!

Perspective on recent developments and challenges in regulatory and systems genomics academic.oup.com/bioinformatics… is out, amazing to think about this with Julia Zeitlinger (@[email protected]), Ferhat Ay, Shaun Mahony, Anthony Mathelier, Alejandra Medina-Rivera, Jason Ernst!