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We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ nature.com/articles/s4159…

I'm happy to share the final version of our paper in nature this week, with a lot of new data! 📄: nature.com/articles/s4158… This would have been impossible without support from the NIH (especially BRAIN Initiative), as well as HHMI, Simons Foundation, Princeton Neuroscience Institute, HHWF, BRF.

The 2025 Breakthrough Prize in Life Sciences goes to Alberto Ascherio, who showed the key risk factor for multiple sclerosis is infection with the Epstein-Barr virus; and to Stephen Hauser, who discovered central mechanisms of the disease and developed life-changing treatments

Well-deserved congratulations to Dr. Hauser! Anti-CD20 antibodies have been a game-changer for multiple sclerosis (and other neuroimmunologic diseases).

How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

Impressive quantitative advance.

With new (unpublished) orforglipron results shifting valuations of ancient pharma diabetes rivals by $100m (LLY⬆️ NVO⬇️), what will be the next small-molecule peptide-receptor agonist to market?

Materials and Methods sections in scientific papers:

Had a lovely time visiting WashU Medicine Anesthesiology Research. It is inspiring to see this program thriving & was a pleasure to spend time with Drs. Vijay Samineni, Rob Gereau, Aaron Norris, Ben Palanca, Michael Avidan, my old friend Dan Emmert, and others.

Alzheimer's Brain Edema, Bleeding Rates Reported in Lecanemab Real-World Study medpagetoday.com/neurology/alzh…

This looks promising -- a method that constrains anterograde transsynaptic tracing to a specific (e.g. Cre-expressing) subtype of neurons: nature.com/articles/s4159…

Is there an optimal lesion target for tremor relief that avoids side effects? Melissa Chua, MD Center For Brain Circuit Therapeutics analyzed over 350 patients who received high intensity focused ultrasound to find one. Reproducible across surgeons and centers.

Thank you to all who served and sacrificed for our freedom. (Iowa City VA this morning)

Craving a salty snack? A new study from UI researcher Joel Geerling could reshape how we understand taste and cravings. foriowa.info/saltdoc

“Draw a picture of what it’s like to talk to me” GPT4o:

“Draw a map of my mind” GPT4o:

Apparently, a 128 Hz tuning fork can be used for so much more than a peripheral nerve exam! I wonder what they will do when they discover the Rydel-Seiffer…