Online Now: Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps dlvr.it/TLjsMp

🧬Motifs are the new BLAST Folddisco scans 53M AlphaFold structures for catalytic, binding or allosteric patterns in seconds🔎 18× quicker, 3.5× smaller, hits in seconds🌌

Online Now: Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures dlvr.it/TMFSGf

Phil and Penny Knight announced today a record-breaking $2 billion gift to the Oregon Health & Science University’s Knight Cancer Institute to transform the future of cancer care and set a new standard globally. Thank you to Phil and Penny Knight for their incredible generosity.

Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications dlvr.it/TMWGK8

Prompt-to-Pill: Multi-Agent Drug Discovery and Clinical Simulation Pipeline 1. This novel study introduces Prompt-to-Pill, a comprehensive AI-driven framework that integrates drug discovery and clinical trial simulation from target identification to virtual patient recruitment.

Nature research paper: Expanding the cytokine receptor alphabet reprograms T cells into diverse states go.nature.com/4loHqOI

Online Now: Dendritic cells function beyond antigen presentation dlvr.it/TMYSP6

My lab (kather.ai) will soon be looking for multiple postdocs / research software engineers in the field of agentic AI in cancer research. Our team recently published the first tumor board agent and we are planning to scale this up nature.com/articles/s4301… Other

AI is challenging the paradigm of "undruggable" cancer targets. Our new Nature Biotechnology comment outlines how AI-driven approaches, from modeling protein complexes to designing novel biologics, can unlock these intractable proteins nature.com/articles/s4158…

Collaboration, not competition, will map the future of human biology. The Billion Cell Project brings together 10 institutions, over 100 experts, 10 research centers + a shared vision: unlocking biological insight at #SingleCell resolution. bit.ly/3U31D1e

We have a new collection of protein structure generative models which we call Protpardelle-1c. It builds on the original Protpardelle and is tailored for conditional generation: motif scaffolding and binder generation.

Excited to share our new paper, out today on Nature Genetics where we use 421 #WGS to reconstruct the evolutionary history of multiple myeloma #mmsm (🔥🔥). Great collaboration with Heidelberg Myeloma Sylvester Comprehensive Cancer Center Mayo Clinic Memorial Sloan Kettering Cancer Center MSK Department of Medicine ⁦.

🧬 Dr. Mikael Dolsten is joining the @ChaiDiscovery board! In 15 years as @Pfizer's Chief Scientific Officer he: ⚛️ Progressed 150 molecules to clinical trials 💊 Delivered 36 approved medicines, from vaccines to cancer therapies

Thrilled to share our new work published in Nature (rdcu.be/eBCM0). We report an exciting new potential therapeutic strategy with a fascinating mechanism of action for cancers with a compromised G1–S cell cycle checkpoint, including SCLC. nature.com/articles/s4158…

#InterferonPower! Thrilled for our latest work Cell! With Daniel Böhmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKGL7PXuFTj

Delighted to share our Cancer Cell paper published today, co-authored by Dr. Alexander Biederstädt Alexander Biederstädt, MD and Dr. Rafet Basar Rafet reporting the first genome-wide CRISPR screen in primary cord blood NK and CAR NK cells. We identify key genetic checkpoints including

Very proud of these two! Kellie Wise (Kellie Wise) Anna Pascual-Reguant Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸 Holger Heyn CNAG St. Jude Research #STAMP Imaging-based multimodal profiling of single cells with STAMP | Nature Reviews Genetics nature.com/articles/s4157…

We’re excited to announce our acquisition of Paige, an AI company specializing in digital pathology. This acquisition allows us to grow our dataset, expand our experienced technical team, and establish a strong footprint in digital pathology with an industry leading

Welcome Paige to Tempus.  Together, we're about to take a giant step forward in bringing AI to diagnostics as combined we have one of the largest libraries of digital pathology images connected to rich clinical and molecular insights in the world. Given our combined AI