Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by Mariana Noto published Science Magazine addresses this fundamental question (1/n) science.org/doi/10.1126/sc…

Our preprint on “Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides” is now available from ChemRxiv 🧪🧫. Congratulations to first author Kevin Schiefelbein and everyone else involved 🥳 chemrxiv.org/engage/chemrxi… Hartrampf Lab

Excited to share the latest Link lab paper on the uptake of lasso peptide antibiotic cloacaenodin into susceptible bacteria. The work was led by Drew Carson in the Link lab and another collab with Zhongyue (John) Yang. pubs.acs.org/doi/full/10.10…

Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria (C. Melander et al.) Melander Lab onlinelibrary.wiley.com/doi/10.1002/cb…

I want to (belatedly) share our new publication in PLoS Genetics - journals.plos.org/plosgenetics/a…

The latest Link lab paper is out J. Am. Chem. Soc. today led by Brian Choi: pubs.acs.org/doi/10.1021/ja…. In this work we show that ATP grasp enzymes that usually make esters can also make thioesters.

Excited to release our latest work, led by Sebastian Gonzalez La Corte (Sebastian Gonzalez La Corte) with Ned Wingreen: doi.org/10.1101/2024.0…! Here, we show that polymers unexpectedly sculpt proliferating bacterial colonies into spaghetti-like "cables".🦠🍝 Tweetorial follows! [1/10]

Our chemical synthesis of PTM-modified MYC peptides and their interactions with the tumor suppressor Bin1 is online Chemical Science. Congratulations @elysetwilliams, @rebeccabev5, Oliver Zerbe, and everyone else involved! 🎉 pubs.rsc.org/en/content/art… #MyFirstChemSci

Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in J. Am. Chem. Soc.! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/ja… UZH Chemistry Hartrampf Lab

Psst. Hey. Yeah you. Want to build 100s to 1000s of plasmids (*any sequence* up to ~6000 bp) for about $10 to $40 each? salislab.net/software/build… Try it out ... feedback is welcomed & encouraged :)

Excited to be at Boston Bacterial Meeting (BBM) at Boston Univ! Looking forward to some great science #BBM2024 🧫 I’m presenting poster number 104 tomorrow, come say hi!

Emergence of a distinct mechanism of C–N bond formation in #photoenzymes by Felix C. Raps Felix Raps, Ariadna Rivas-Souchet, Chey M. Jones Chey Jones, Ph.D., and Todd K. Hyster @HysterLab at Princeton Chemistry nature.com/articles/s4158…

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55

The latest Link lab paper is out Biochemistry!: doi.org/10.1021/acs.bi… This work, led by Angela Zhu, focuses on the cysimiditides, a new subfamily of #RiPPs. The cysimiditides include a tetracysteine motif that coordinates a zinc ion and a single aspartimide moiety.