Role of ACE2 in the negative regulation of Renin Angiotensin System. Angiotensin II formed by ACE2 activates AT1R. ACE2 degrades Angiotensin II to Angiotensin 1-7. AT(1-7)R aka Mas is vasodilatory and helps protect from excessive AT1R activation Thnks @NortinHadlerMD #COVID19 3/n

This is an oncologist's struggle in the time of #COVID19. And while I appreciate the optimism of the phrase "ideally, no delay," many doctors and patients alike are forced to choose from suboptimal options. annals.org/aim/fullarticl…

So $BIIB, $LLY, $REGN, and $AMGN are all working on monoclonal antibody partnerships against #COVID19, yet a neutralizing antibody exists in ACE2-Fc against all viral isolates that they all could have been making since January. #fightgroupthink f1000research.com/articles/9-72

Just Published Online: #OnMyMind Angiotensin-(1-7) may be useful to protect the lungs of high risk patients infected with SARS-CoV-2 responsible for the Covid-19 pandemic.#COVID19 #AHACOVID19 AHA Science ow.ly/ZPZa50z4q3B

“This is likely a once-in-a-generation disaster, and it will affect every domain of human life. It will be traumatic. And trauma always falls hardest on the youngest among us.” The COVID-19 Crisis Is Catastrophic for Children Too - Bruce Lesley - Medium bit.ly/2yvslZV

1/ 【🇯🇵JAPAN】Nafamostat/Camostat【COVID19】 Let me share one of the #COVID19 solutions in 🇯🇵Japan, using existing Japanese 【pancreatitis drug】, Nafamostat, which is expected to 【prevent】 the transmission of the #NovelCoronavirus infection. (continue)

Van Gogh's paintings can come to life thanks to AI.

Answer for difficult questions in Childhood: pedmindexpertrelation.com

Arginase 1 Deficiency: ultrarare, only 8-10000 patients worldwide and to date no enzyme replacement with crossing the blood Brain Barrier.

Small Interfering RNA (siRNA) Technology Provides silencing of defect genes in Huntington Disease and KCNT1-disorder in Mouse Models (ATL-101 and ATL-201).

The promise of nanotechnology-based drug delivery systems (DDSs) is to deliver nucleic acids selectively to the target tissues and cells with increased efficacy while reducing side effects.

Dengue Suppression by Male Wolbachia-Infected Mosquitoes | New England Journal of Medicine nejm.org/doi/full/10.10…

Castleman disease is rarely found in Pediatric Population, unicentric/multicentric. more often found in Teenagers. Good prognosis.

Osteogenesis imperfecta: 8 types, some are mild-some lethal; only Type 1 has blue sclera, type 2-8 not. Often glycine substitutions in COL1A1/2, but not in all types. Sclerostin inhibitors could be helpful, but could have Influence on blood viscosity ( heart infarction, stroke)

Gene silencing shows promise as a targeted therapy for osteogenesis imperfecta (OI), a genetic disorder caused by dominant mutations in COL1A1 or COL1A2 genes that disrupt type I collagen production, leading to brittle bones.

CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | New England Journal of Medicine nejm.org/doi/full/10.10…

Hypochondroplasia is an attenuated Form of achondroplasia, Both are FGFR3-related. An overactive FGF3 receptor has to be highly selective inhibited by a drug, TYRA-300 (Dabogratinib) could be the future in Both entities to „treat“ effectively without toxic side effects.