Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes go.nature.com/46OFcoj

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs: nature.com/articles/s4155…

Harvard Gazette covers our breakthrough: the world’s first scar-free brain implant succeeds in human trials! Next up: large-scale clinical studies. A big step for neurotech & #BCI innovation. news.harvard.edu/gazette/story/…

GPT-5 coding cheat sheet from OpenAI Developers

Science fan comic for cool work from Dr. Sandra March in the Bhatia lab at MIT/HHMI on building in vitro liver clocks to understand rhythms in infection and drug metabolism 💕 science.org/doi/10.1126/sc…

A recent survey of nearly 900 postdocs at the Max Planck Society reveals: 🔹 28% show signs of severe depression 🔹 25% struggle with severe anxiety 🔹 More than half oppose contract caps that force them out after 4–6 years 🔹 International researchers (75% of the cohort) face

Just out in J. Am. Chem. Soc. now from IISc Bangalore: Enantioselective Total Synthesis of [5]-Ladderanoic Acid pubs.acs.org/doi/10.1021/ja… Congratulations Sayan Ray, Deepak, and Prava. Thank you, Pradip and Subrata, for a fruitful collaboration. Thank you Syngene Intl & SERB

🗝️The right drug molecule will bind to a protein to treat a disease. But what about "undruggable targets"? #JClinic PIs Regina Barzilay & Marzyeh co-authored a new paper in Nature Biotechnology w/ 15 co-authors on how AI could challenge drug design. nature.com/articles/s4158…

I made an interactive enzyme simulator. Change the temperature, add or remove inhibitors, and tune the probability that enzymes bind their substrates. Watch as the reaction rate moves up or down in real-time. Maybe this will be a helpful teaching tool.

These are the 25 highest-cited papers published this century. Why are they breaking records? go.nature.com/41LzujC

We are looking for a postdoc to join our team at Monash Institute of Pharmaceutical Sciences (MIPS). If you have a PhD in organic chemistry, ideally with a background in protein chemistry or chemical biology you might be the ideal fit for our team. share.google/vDuCu0x8UfKj0P…

First preprint from Simlandy Lab IISER Berhampur is out now in ChemRxiv We observe interesting mechanistic divergence with increasing conformational rigidity. chemrxiv.org/engage/chemrxi… Pratap Kumar Mandal Subhra kanti Mahato Soumalya Panja Parikshit Moitra

MIT Course announcement: Machine Learning for Computational Biology #MLCB25 Fall'24 Lecture Videos: tinyurl.com/MLCBlectures Fall'24 Lecture Notes: tinyurl.com/MLCB24notes (a) Genomes: Statistical genomics, gene regulation, genome language models, chromatin structure, 3D genome

Next week! See how Prof. Taekjip Ha uses single-molecule tools to uncover how proteins search and reshape chromatin in real time. You don’t want to miss this! bit.ly/45cKiJM

Out today: A useful review on AI-designed protein binders. It covers the history of this work + has lots of good case studies, including how these tools are being used to make snake anti-venoms. The tables are particularly valuable.

New in PNASNews with Gladfelter Lab , Wilton Snead, & Mary Skillicorn from my lab! 📢 Cells use condensates (dynamic compartments without membranes) to organize key reactions. Some have core & shell layers.. but how do such layers form? 🤔 👉 pnas.org/doi/10.1073/pn… (1/6)

Download BLAST+ 2.17.0 now for faster BLAST protein searches! This release includes a new CSV output format with headers for easier data handling. Learn more: blast.ncbi.nlm.nih.gov/doc/blast-news…

A theory with mathematical beauty is more likely to be correct than an ugly one that fits some experimental data. -- Paul A. Dirac

#OnThisDay in 5 September 1985, scientists generated fullerenes (also known as Buckyballs) for the first time. Robert Curl Jr, Sir Harold Kroto and Richard Smalley received the 1996 #NobelPrize in Chemistry for their discovery, which is now used in nanotechnology.

Following injury from a heart attack, immune cells called neutrophils release a peptide that punctures stressed heart cells and destabilizes their electrical activity. This triggers life-threatening arrhythmias. These findings in Science offer a novel explanation—and potential