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I can't get over these 3D spatial images in the latest preprint from Peter Sorger Ajit Johnson Nirmal et al. The preprint is a roadmap on how to conduct 3D cyclic immunofluorescence using "thick" archival sections and precisely map cell-cell interactions biorxiv.org/content/10.110…

Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury: Neuron cell.com/neuron/fulltex…

Delighted to share Dinoto et al study on late onset MOGAD (50 yrs or more) ➡️ Accounts for 25% of MOGAD ➡️ Optic neuritis dominates & often misdiagnosed as ischemic (NAION or temporal arteritis) ➡️ Outcomes favorable & similar to other age groups 👇 neurology.org/doi/10.1212/WN…

Important study! Congrats to AleDinoto, Eoin Flanagan and all the colleagues involved!

Common neuropathologic change drivers of hippocampal sclerosis of ageing #neuropath academic.oup.com/brain/advance-…

Perivascular radial enhancement is a radiologic hallmark of autoimmune GFAP astrocytopathy, but is this diagnosis on your differential for leptomeningeal enhancement? Check out this #NeurologyRF Pearls & Oy-sters 🦪 for more! neurology.org/doi/10.1212/WN…

Thanks for highlighting this work. The patients we are seeing continue to teach us so much!

Toxic neuropathies are not as easy as one may think. There is no other kind of neuropathy for which history and neurological examination are so crucial for the diagnosis, as no definitive diagnostic tests are available. In addition, it is important to review the medical records

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuroinflammation leading to dysregulation of oligodendroglial cells and impaired cognition cell.com/cell/fulltext/…

NEWS from the GCIR about #TCell mediated #neurodegeneration! Read about the mechanisms behind #AutoimmuneEncephalitis cases where the immune response targets intracellular #antigens Summary: bit.ly/43qXgTb Full: doi.org/10.1007/s00401… UNIGE_en HUG Giovanni Di Liberto

Chronic stress drives depression by disrupting cellular housekeeping nature.com/articles/d4158…

IFN-γ orchestrates anti-tumor responses against leptomeningeal metastasis through an unexpected series of cell–cell interactions: cDC maturation and NK cell activity nature Adrienne Boire nature.com/articles/s4158… nature.com/articles/d4158…

The race to reset autoimmune diseases nature.com/articles/d4157…

Microglia transcriptional states and their functional significance: Context drives diversity🫶 cell.com/immunity/fullt…

Science Astrocytes, hidden puppet masters of the brain science.org/doi/10.1126/sc…

Powerful cell therapies used to treat cancer can unleash immune responses that damage the brain go.nature.com/3SapnQh

Progress (but caution) toward Mitigating Disability Progression in Multiple Sclerosis | Editorial by Peter Calabresi nejm.org/doi/10.1056/NE…

Teaching NeuroImage: Primary Central Nervous System Vasculitis With Thalamic Involvement hubs.la/Q03mS2tN0

A 17-year-old boy with AQ4+ #NMOSD and treated with rituximab, had JCV+ progressive multifocal leukoencephalopathy #PML, which resulted into death. Case report from The Walton Centre Monash University ▶️journals.sagepub.com/doi/full/10.11… 1/🧵