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Had a great first time at #SMBE2024! Was thrilled and grateful to present my work on “The trait specific timing of accelerated genomic change in the human lineage” which also has a preprint available at doi.org/10.1101/2022.0… Mashaal Sohail Vagheesh Narasimhan

Devansh Pandey and Liaoyi Xu also presented posters: “Leveraging ancient DNA to uncover signals of natural selection in Europe lost to admixture or drift” and “The genetic architecture and consequences of the human pelvic form”. Check out what the Vagheesh Narasimhan Narasimhan lab is up to!

Overall saw some great talks, met awesome folks in the #SMBE community, and enjoyed the food and culture of Puerto Vallarta. Thanks to all the SMBE organizers for their work and looking forward to the next one!

Announcing the BioML Challenge 2024: Bits to Binders! In this 5-week competition, teams will use AI methods to design protein binders that bind to a target antigen and activate an immune response from its associated CAR-T cell. Real-world scenario. With wet lab validation!

Check out this amazing hackathon by BioML society at UT Austin. It involves use of AI for protein design followed up by experimental validations.

Excited to share my 1st-author work from the @arbelharpak Lab! We examine the accuracy of polygenic score (PGS) predictions across individuals in the UK Biobank. We make 3 observations that expose gaps in our understanding of PGS “portability”. biorxiv.org/content/10.110… (1/28)

Stoked to see our Bits to Binders protein design competition covered in nature News today alongside Adaptyv Bio, EvolutionaryScale, and The Align Foundation! We just wrapped up the design stage of our comp, stay tuned for a update in the coming days! nature.com/articles/d4158…

Exploring #MultimodalAI for disease diagnosis? Stop by my poster (5128W) today at #ASHG2024 from 2:30-4:30 pm – excited to share insights and connect!

Delighted to share that our paper on discovering selective sweeps with haplotype statistics in aDNA is now out in Nat. Comm! Wonderful collaboration with Vagheesh Narasimhan, Devansh Pandey, and Mariana Harris.

Happy to share our recent publication in the Journal of Hydrology. Our study examines water and carbon fluxes from a supra-permafrost aquifer into Imnavait Creek, a headwater stream in Alaska’s continuous permafrost region. Link to paper: doi.org/10.1016/j.jhyd…

nature.com/articles/s4225… Another paper that produces a GWAS for unsupervised imaging phenotypes but my main issue is interpretability. What do I do with a PRS for latent vector 14 of the heart, or it's effect size? If you care about disease prediction, don't need IDPs at all

Scientists from UT Austin & UCLA used ancient DNA samples to look back in time & reveal new insights into how ancient Europeans adapted to their environments over 7,000 years of European history. #AncientDNA UT Statistics and Data Sciences Integrative Biology Vagheesh Narasimhan dugdheswor pandeya cns.utexas.edu/news/research/…

New paper led by star PhD student Michael R. Schwob (who is currently on the statistics job market) building a bayesian hierarchical model to understand gene flow across space and time in ancient DNA datasets. academic.oup.com/biometrics/art…

HORNS UP. THUMBS DOWN.

When in evolutionary time does accelerated genomic change occur across phenotypes? Newly published today in Cell Genomics , my latest manuscript with Mashaal Sohail and Vagheesh Narasimhan integrates comparative, functional, and ancient genomic data with GWAS. Read more: cell.com/cell-genomics/…

on twitter, you will always find someone who is tweeting your thoughts but with better grammar.

In a new paper, colleagues and I raise concerns about the conclusions and data from Zhang et al 2022, a paper which reported that they obtained DNA from a 14-thousand-year-old individual from Red Deer Cave in Yunnan China referred to as ‘Mengzi Ren’ (MZR) (Zhang et al Fig 1) 1/15

Excited to share our new study just published in Science Magazine, led by Liaoyi Xu! Check it out.