Darshini Poola (@darshini_poola) 's Twitter Profile
Darshini Poola

@darshini_poola

She/Her | Research Associate @GladstoneInst | BS-MS @IISERPune 2019-24 | Genomic Engineering | I write/sketch, sometimes | Bookworm @ tteok-book-i (link below)

ID: 1273318235690029057

linkhttp://tteok-book-i.medium.com calendar_today17-06-2020 18:17:16

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Seth Shipman (@seth_shipman) 's Twitter Profile Photo

New Preprint, New Retrons! More than a hundred of them. We synthesized a ton of bioinformatically predicted retrons and put them through a battery of tests, from RT-DNA production to editing in human cells, E. coli, and phage biorxiv.org/content/10.110… Gladstone Institutes UC San Francisco UCSF Bioengineering & Therapeutic Sciences

Seth Shipman (@seth_shipman) 's Twitter Profile Photo

Multitrons: simultaneous multi-site editing of individual genomes using retron arrays, now published in Nature Chemical Biology Nature Chemical Biology: nature.com/articles/s4158…. Great job Alex González-Delgado and oso !

kate crawford (@katecrawdaddy) 's Twitter Profile Photo

So excited to share one of the final works from my PhD in Seth Shipman’s lab with Asim Khan and oso, where we used high-throughput libraries and machine learning to create design rules for retron gene editors: biorxiv.org/content/10.110…

Darshini Poola (@darshini_poola) 's Twitter Profile Photo

It has been an exciting and enlightening journey navigating my master’s project. Couldn't have been more grateful for the opportunity and mentorship 😇

Gladstone Institutes (@gladstoneinst) 's Twitter Profile Photo

A team at Gladstone developed a technology that lets them edit the genomes of bacteria-fighting viruses, known as phages, in a streamlined and highly effective way. Read more about this new study: bit.ly/3XIW4rL

A team at Gladstone developed a technology that lets them edit the genomes of bacteria-fighting viruses, known as phages, in a streamlined and highly effective way.

Read more about this new study: bit.ly/3XIW4rL
Seth Shipman (@seth_shipman) 's Twitter Profile Photo

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

Seth Shipman (@seth_shipman) 's Twitter Profile Photo

🚨New Pub: High throughput variant libraries and machine learning yield design rules for retron gene editors, now out in Nucleic Acids Res. This is a great one, and the last bit of kate crawford's PhD, who is off to David Bakar's Lab for a postdoc. academic.oup.com/nar/advance-ar…