Rebecca Fang from Seth Shipman's lab presents her work on using PacBio technology to sequence the mitochondrial genome. Gladstone Institutes

New Preprint, New Retrons! More than a hundred of them. We synthesized a ton of bioinformatically predicted retrons and put them through a battery of tests, from RT-DNA production to editing in human cells, E. coli, and phage biorxiv.org/content/10.110… Gladstone Institutes UC San Francisco UCSF Bioengineering & Therapeutic Sciences

Multitrons: simultaneous multi-site editing of individual genomes using retron arrays, now published in Nature Chemical Biology Nature Chemical Biology: nature.com/articles/s4158…. Great job Alex González-Delgado and oso !

An explainer/behind-the-scenes: gladstone.org/news/new-one-s… via Gladstone Institutes.

So excited to share one of the final works from my PhD in Seth Shipman’s lab with Asim Khan and oso, where we used high-throughput libraries and machine learning to create design rules for retron gene editors: biorxiv.org/content/10.110…

Continuous multiplexed phage genome editing using recombitrons go.nature.com/3yUNYTi

It has been an exciting and enlightening journey navigating my master’s project. Couldn't have been more grateful for the opportunity and mentorship 😇

Multiplexed editing of phage genomes using retrons, now published at Nature Biotechnology with lots of new bells and whistles. chloe kate crawford Santi Bhattarai-Kline Darshini Poola Karen Zhang Alex González-Delgado Matías Rojas Montero nature.com/articles/s4158…

New technology could lead to alternative treatments for antibiotic-resistant bacteria #NBTintheNews via Gladstone Institutes gladstone.org/news/new-techn…

A team at Gladstone developed a technology that lets them edit the genomes of bacteria-fighting viruses, known as phages, in a streamlined and highly effective way. Read more about this new study: bit.ly/3XIW4rL

🚨 NEW PUBLICATION 🚨 "Continuous multiplexed phage genome editing using recombitrons" Seth Shipman kate crawford chloe Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network go.nature.com/3yUNYTi

Gladstone Institutes Phage therapy could leverage retrons to overcome antibiotic resistance #NBTintheNews via Genetic Engineering & Biotechnology News genengnews.com/topics/infecti…

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

Again from Seth Shipman lab Gladstone Institutes, a compendium of retrons! nature.com/articles/s4158…

An experimental census of retrons for DNA production and genome editing go.nature.com/3MOsMBx

🚨 NEW PUBLICATION 🚨 "An experimental census of retrons for DNA production and genome editing" Seth Shipman Asim Khan Matías Rojas Montero Alex González-Delgado Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network nature.com/articles/s4158…

Have you seen this new publication from the Shipman Lab? Shoutout to the team and collaborators ⤵️ ⤵️ Seth Shipman Asim Khan Matías Rojas Montero Alex González-Delgado Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network nature.com/articles/s4158…

ICYMI: "An experimental census of retrons for DNA production and genome editing" in Nature Biotechnology nature.com/articles/s4158…

🚨New Pub: High throughput variant libraries and machine learning yield design rules for retron gene editors, now out in Nucleic Acids Res. This is a great one, and the last bit of kate crawford's PhD, who is off to David Bakar's Lab for a postdoc. academic.oup.com/nar/advance-ar…

Now published Nucleic Acids Res! SspA is a transcriptional regulator of CRISPR adaptation in E. coli. academic.oup.com/nar/advance-ar…