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CZI Science

@cziscience

Science news and updates from the Chan Zuckerberg Initiative @ChanZuckerberg

ID: 870364054044520448

linkhttps://chanzuckerberg.com/science calendar_today01-06-2017 19:38:55

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Picture this: 🔬 AI simulations that predict how disease begins in a single cell 🧫 Imaging tools that make what was invisible visible 🌡️ Biosensors that track inflammation in real time 🛡️ Immune cells that seek out + stop disease That future? It’s what we're building, right now

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Dmitry Fishman was inspired to create a simple, user-friendly way of seeing chemistry in real time in tissues. His team's new infrared detection method could help researchers see chemical processes in: 🔬 Cancer 🔬 Histopathology 🔬 Tissue dynamics

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By sharing insights into the inner workings of deep neural networks, Su-In Lee is developing foundational AI principles + techniques to address new scientific questions. Her work has the potential to significantly advance #SingleCell biology 📸Mark Stone

By sharing insights into the inner workings of deep neural networks, <a href="/suinleelab/">Su-In Lee</a> is developing foundational AI principles + techniques to address new scientific questions. Her work has the potential to significantly advance #SingleCell biology
📸Mark Stone
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🌟New 🌟Our AI model TranscriptFormer is the first multispecies generative model for #SingleCell transcriptomics. bit.ly/42AvbbS

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"We've been in the data set generation business for quite a while—with CELLxGENE and now our Billion Cells Project—to enable the next set of breakthroughs with AI." #CZBiohubCHI President Shana Kelly shares how we’re tackling big questions in human health at #SCSPAIExpo2025

"We've been in the data set generation business for quite a while—with CELLxGENE and now our Billion Cells Project—to enable the next set of breakthroughs with AI." #CZBiohubCHI President Shana Kelly shares how we’re tackling big questions in human health at #SCSPAIExpo2025
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Greater insight into how each distinct cell operates within us will transform human health. At #SCSPAIExpo2025, @jcoolscience is sharing how partnerships + cell data generation with the Billion Cells Project will open scientific doors to discovery

Greater insight into how each distinct cell operates within us will transform human health. At #SCSPAIExpo2025, @jcoolscience is sharing how partnerships + cell data generation with the Billion Cells Project will open scientific doors to discovery
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David Maresca + teams at TU Delft, Caltech & NIN used nanoscale, gas-filled vesicles as acoustic reporters to achieve deep-tissue imaging of labeled cells + microvasculature science.org/doi/10.1126/sc…

David Maresca + teams at TU Delft, Caltech &amp; NIN used nanoscale, gas-filled vesicles as acoustic reporters to achieve deep-tissue imaging of labeled cells + microvasculature science.org/doi/10.1126/sc…
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Mitochondrial networks + DNA-protein complexes in live Caenorhabditis elegans revealed by Airyscan fluorescence microscopy 📸 S Lewis

Mitochondrial networks + DNA-protein complexes in live Caenorhabditis elegans revealed by Airyscan fluorescence microscopy 

📸 <a href="/SamLewisPhD/">S Lewis</a>
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Imaging scientist Martin Fischer is developing new ways to use short laser pulses in a microscope to visualize the structure and function of cells in biological tissue without damaging them—and keep these imaging technologies broadly accessible

Imaging scientist Martin Fischer is developing new ways to use short laser pulses in a microscope to visualize the structure and function of cells in biological tissue without damaging them—and keep these imaging technologies broadly accessible
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Baseline immune states that mimic adjuvant-induced responses = better vaccine outcomes. #CZBiohubNY ’s John Tsang @tsanglab.bsky.social introduces “natural adjuvanted” setpoints, uncovered via AI. Yale School of Medicine Dig into the science ⤵️ doi.org/10.1146/annure…

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Oliver Bruns is pushing the boundaries of optical imaging by harnessing the infrared spectrum. His team is developing cutting-edge labels + techniques for ultra-clear 3D imaging

Oliver Bruns is pushing the boundaries of optical imaging by harnessing the infrared spectrum. His team is developing cutting-edge labels + techniques for ultra-clear 3D imaging
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Light microscopes hit a wall with opaque tissue. This new ultrasound modality developed by David Maresca + teams at TU Delft, Caltech & NIN sidesteps that by reflecting sound off gas vesicles + microbubbles—non-invasively science.org/doi/10.1126/sc…

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Meet Anna Jost, her dream is to bring imaging science education to new audiences—researchers + fellow educators alike #ImagingTheFuture

Meet Anna Jost, her dream is to bring imaging science education to new audiences—researchers + fellow educators alike #ImagingTheFuture
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.Royal Brompton CMR Physics Group are #ImagingTheFuture by 🔬Developing novel diffusion encoding schemes to map 3D cell orientations despite cardiac/respiratory motion 🔬Integrating diffusion MRI data into microstructure models informed by microscopy 🔬Leveraging AI for super resolution

.<a href="/RBHCMRPhysics/">Royal Brompton CMR Physics Group</a> are #ImagingTheFuture by 

🔬Developing novel diffusion encoding schemes to map 3D cell orientations despite cardiac/respiratory motion

🔬Integrating diffusion MRI data into microstructure models informed by microscopy

🔬Leveraging AI for super resolution
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Dimensionality reduction, interpretability and deep learning—all part of the ML toolkit transforming human immunology. John Tsang @tsanglab.bsky.social outlines strategies to make sense of massive immune datasets. #CZBiohubNY Yale School of Medicine doi.org/10.1146/annure…

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Knowing that molecular pathological biomarkers can more accurately predict patient diagnosis & prognosis compared to histomorphological analysis alone, neurosurgeon Jakob Strähle + team are developing rapid, reliable chemical imaging methods to improve oncological surgeries

Knowing that molecular pathological biomarkers can more accurately predict patient diagnosis &amp; prognosis compared to histomorphological analysis alone, neurosurgeon Jakob Strähle + team are developing rapid, reliable chemical imaging methods to improve oncological surgeries
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Virtual staining offers a promising approach to map dynamic cellular systems across various cell types + conditions, broadening the scope of live-cell imaging. Congrats to Shalin Mehta & the team at #CZBiohubSF 🎉🙌 bit.ly/4jZJCvg

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This image shows PSFs at equal radii, rotated around the field of view. In Amit Kohli’s method, these are treated as symmetry-equivalent. That assumption powers ring deconvolution—offering near-isotropic resolution from a single calibration. More nature bit.ly/3TqTbJb

This image shows PSFs at equal radii, rotated around the field of view.
In Amit Kohli’s method, these are treated as symmetry-equivalent.
That assumption powers ring deconvolution—offering near-isotropic resolution from a single calibration.
More <a href="/Nature/">nature</a> bit.ly/3TqTbJb
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“The neuron is the most basic unit of the nervous system, but we know surprisingly little about how it works!” Adam Cohen is developing new tools to map electrical impulses in neurons, helping to reveal how cells interact as systems

“The neuron is the most basic unit of the nervous system, but we know surprisingly little about how it works!”

<a href="/AdamEzraCohen/">Adam Cohen</a> is developing new tools to map electrical impulses in neurons, helping to reveal how cells interact as systems