Congratulations Dr Rose Hodgson! Was an absolute pleasure to have you in the lab, already missing the fancy dress Cornall_lab Centre for Human Genetics

I dunno, you guys. It seems like the "B is for Boring" slogan might have been a campaign funded by Big B Cell. Those guys are up to some nefarious stuff! nature.com/articles/s4159… Anyway, T cells to the rescue!

Looking forward to applying this to DKD with Jessica Kepple

Fantastic talks and fabulous science at the Oxford Imaging Symposium 2022 today!

Our new paper: NDRG1 is an anti cancer therapeutic target, upregulated in anergic B cells, and previously described as a T cell anergy factor, but we show it is not required for B or T cell tolerance. work led by Rose Hodgson, with Cornall_lab Nuffield Department of Medicine rdcu.be/cZska

NDRG1 is a target for cancer treatment. But it was also thought to help immune cells 'switch off', so NDRG1 drugs might cause immune over-activity. However we show that although NDRG1 goes up in these immune cells, they don't need NDRG1 to switch off. rdcu.be/cZska

Our lab and Cornall_lab giving some thanks

I’m completely thrilled to share our new preprint! Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics arxiv.org/abs/2212.06505 Joint work with Aneesha Bhandari, BGI Genomics, Ulrike Tillmann, Katherine Bull, and Heather Harrington 1/9

Chimeric experiments highlight a population of KLRG1+ effector T cells, only observed in association with the autoimmune phenotype.

Beautiful T cell single cell analysis by Rose Hodgson shows increased effectors and significant reduction in Ly6c2+ central effector memory.

Thanks also to: Tanya Crockford, Aneesha Bhandari, Jessica Kepple, Jenny Back, Eleanor Cawthorne, Lucie Abeler-Dorner, Adam Laing, Simon Clare, Annie Speak, David Adams Professor Gordon Dougan FRS Immunosurveillance @TheCrick & @KingsCollegeLon Mukta Deobagkar Cornall_lab Centre for Human Genetics OxfordGenomicsCentre

Just published! Prolidase deficient mice have increased incidence of anti-nuclear antibodies, immune complex deposition and altered T cell population composition. journals.aai.org/jimmunol/artic…

We demonstrate that the autoimmune phenotype is associated with a populations of effector CD8 T cells with a phenotype similar to short lived effector cells (SLEC) in viral infection. Read on to find out more: journals.aai.org/jimmunol/artic… Katherine Bull

#AuthorChoice: Prolidase deficiency causes spontaneous #Tcell activation and #lupus-like #autoimmunity | from Katherine Bull University of Oxford #FreetoRead #ReadTheJI #immunology 👉 ow.ly/Cmxo50MVZOF

Very pleased to have my first PhD publication published in Immunotherapy Advances Journal. Using humanised mice we trialled the combination immunotherapy of nivolumab and OX108 (a CD200R blocker) in two tumour models. Davis Lab Oxford Cornall_lab @MRC_HIU MRC WIMM RDM Oxford

Researchers at Davis Lab Oxford investigate the potential of a new combination #immunotherapy of #nivolumab, a clinically approved #PD1 blocking antibody, & OX108, a #CD200R blocker Explore their results in mouse models for colorectal & lung #cancer ➡️bit.ly/3Madlmm

I am really excited to announce that our paper (PaulKlenermanLab) exploring MAIT cell transcriptional and TCR repertoire diversity in human blood and liver has been released Nature Immunology nature.com/articles/s4159… #MAITcells

Exciting postdoc role with our friendly supportive group and Translational Research and Immunology Group Fadi Issa. Cell therapy for IgA Nephropathy, part of EU /Horizon consortium. Do you like immunology, kidneys and translational research? Informal enquires / DMs for more info welcome my.corehr.com/pls/uoxrecruit…

B cells activated by low amounts of antigen require DOCK8 to acquire survival and differentiation signals via T cell help Science Immunology Cornall_lab science.org/doi/10.1126/sc…

Check out our new Science Immunology paper about the role of DOCK8 in the survival and differentiation of B cells activated by low amounts of antigen: doi.org/10.1126/sciimm… A big shoutout to Cornall_lab & Katherine Bull Thank you MRC TIDU Centre for Human Genetics Nuffield Department of Medicine CAMS Oxford Institute