The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites biorxiv.org/cgi/content/sh… #biorxiv_cellbio

nature.com/articles/s4155…

APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease
nature.com/articles/s4159…

Our study is finally out! nature.com/articles/s4153…
We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient.
Thanks to Nils-Göran Larsson , Motori Lab, Thomas Perlmann and Per Svenningsson for the great collaboration!

One more reason we need proteomics - to understand the impact of genetic diversity. The transcriptome alone does not provide a full enough pictures about gene expression differences. Great colleaboration with Joseph Schacherer 's team. More to follow soonish pnas.org/doi/10.1073/pn…

ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Interested in quantitative imaging, iPSC models, organelle function, genome editing, or maybe all of the above☺️? Check out these Project Officer and Research Fellow (postdoc) positions to join my lab in sunny Singapore! bussilab.com
👇👇
ntu.wd3.myworkdayjobs.com/en-US/Careers/…

Thrilled by our collaborative work with Wenting ZHAO @RangaminiUCSD, unveiling how membrane nanotopography dictates actin nucleation via curvature-guided nano-condensation. This nano-engineering approach reshapes our grasp of dynamic biochemical reactions. biorxiv.org/content/10.110…

I wouldn't be in Argentina if it weren't for public education. Today, the University of Buenos Aires is turning off the lights because it can't afford the power. Tomorrow, there's a massive march to defend public education. Re-sharing this 🍏✏️ buenosairesherald.com/society/i-woul…

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice dlvr.it/T5mjw6

Why it is important to image living cells and spend enough time at the microscope....

In eLife - the journal: Golgi Apparatus: Making progress doi.org/10.7554/eLife.…

Attention organelle enthusiasts!!
I am beyond thrilled to introduce Nellie: a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D/3D live-cell microscopy.

paper: arxiv.org/abs/2403.13214
github: github.com/aelefebv/nellie

🧵1/N

Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts biorxiv.org/content/10.110…

More than excited to share Uche's comprehensive review on BMP, a unique lysosomal lipid. We survey the past work of giants in the field, identify open questions to inspire people joining this emerging space and describe the therapeutic potential of targeting the BMP pathway.

Researchers from the global south face often-distressing immigration bureaucracy that most from the global north do not.

These steps can begin to counteract this inequity go.nature.com/3Jl5xx8

Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites: Developmental Cell cell.com/developmental-…

In the latest issue! Infant microbes and metabolites point to childhood neurodevelopmental disorders dlvr.it/T5TxHy

Perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes dlvr.it/T5Mtg4

A validation strategy to assess the role of phase separation as a determinant of macromolecular localization: cell.com/molecular-cell…

✨ New research, led by Ya-Cheng Liao Lippincott-Schwartz Lab, details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions. 🦠

🔗janelia.org/news/starving-…