After 4 years of working at the intersection between AI and biomedicine, I passed my PhD viva last week!😀 My work has focused on using machine learning based methods to impove the reliability of de novo protein design, and to make it more accessible to researchers. 1/3

📢 WE ARE HIRING 📢 Applications are open for a full-time Lecturer in Engineering Biology to join the new EPSRC/BBSRC-funded Engineering Biology Centre for Doctoral Training. Info: bristol.ac.uk/jobs/find/deta… Closing date: 18 June 2024

Our paper on 'Deprotectases' has been published as part of the Faraday Discussions collection on biocatalysis. A team effort, including 9 undergraduates! Chemistry Edinburgh Well done to everyone involved. #FDbiocatalysis pubs.rsc.org/en/content/art…

It was a great talk!

We are hiring a Senior Scientist at C3 BIOTECH (Manchester based). Great opportunity to join a forward thinking and rapidly growing biomanufacturing company linkedin.com/jobs/view/3952…

New paper in PLoS Comp Biol! Jack O'Shea used molecular dynamics to find sites for cpGFP insertion, creating functional biosensors in a periplasmic binding protein. He identified known sites but also discovered new ones, which he validated in the lab. journals.plos.org/ploscompbiol/a…

I have to say, I'm always mildly offended when I get one of those "We are in shortfall of one article for successful release of Volume" emails, asking you to submit a paper. I know it's spam, but I can't help but feel like contacting me is some sort of last resort! 🤣

PEDS: Protein Engineering, Design & Selection is excited to share its latest article collection on "Computational Methods for #ProteinDesign". Free to read until Sept. 30, 2024: academic.oup.com/peds/pages/spe…

7/ Christopher W. Wood and colleagues (Biological Sciences | University of Edinburgh) report the Three-dimensional Inference Method for Efficient Design (TIMED), a convolutional #NeuralNetwork-based algorithm for #InverseFolding. academic.oup.com/peds/article/d…

⏰Last chance to join our 2024 cohort UKRI AI CDT in Biomedical Innovation Applications for this exciting PhD project co-led with Roche close next week

📢 Finally out in J. Am. Chem. Soc.: We engineered the first #PhotoLanZyme, a lanthanide-dependent photoredox enzyme that catalyzes radical C-C bond cleavages upon visible-light irradiation! 💡🧫🧪🧬💻 TU München European Research Council (ERC) pubs.acs.org/doi/10.1021/ja…

We have up to three HiWi (1 year contract) and/or Master's thesis projects in Tuebingen on topics of: i) deimmunization of synthetic cytokines, ii) Optimization of metal-binding proteins, or iii) Characterization of cell-penetrating peptides. Please, get in touch if interested.

The Protein Design Archive (PDA): insights from 40 years of protein design biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Ever wish there was a way to easily browse designed proteins? You're in luck! Introducing the Protein Design Archive - your go-to resource for exploring designed protein structures across the last 40 years! Website: pragmaticproteindesign.bio.ed.ac.uk/pda/ Preprint: biorxiv.org/content/10.110…

Just putting some papers on the timeline:) Looking forward to seeing if we are now in the fourth phase (with deep-learning adding even more designs per year). Also nice to put some numbers onto things people have long suspected (like overrepresentation of alpha helices).

Our new work with Christopher W. Wood introduces the Protein Design Archive (PDA) – a comprehensive database of designed proteins. Explore 40 years of advances in design, with insights on trends, challenges, and new opportunities! 🧬💡 Freely available here: pragmaticproteindesign.bio.ed.ac.uk/pda/

Are you looking to start a PhD in Jan-Apr 2025? Are you interested in developing new ways to make therapeutics using biocatalysis and organic synthesis? Deadline 14th Oct findaphd.com/phds/project/c…

Congratulations to Graham Day, Andrey Zaytsev, Richard Brewster, Valery Kozhevnikov, Amanda Jarvis on their paper out today in Angewandte Chemie Int. Ed. onlinelibrary.wiley.com/doi/epdf/10.10…

Postdoc position alert! We are teaming up with colleagues at UEA, Stellenbosch and CyanoCapture on a CTRFoundation UK funded project to engineer fast-growing cyanobacteria for growth on flue gas to help reduce CO2 emissions. Please do apply if interested jobs.ac.uk/job/DJT883/pos…