One of my greatest lessons in 2022: most people focus too much on downside protection in everyday life. If we tweaked our mental models to be 20% more focused on upside/wins, we’d be far better off. Tweet a half-baked idea. Say the weird thing in a meeting. Act more, think less

New fellowship program, looks very good: osv.llc/oshaughnessy-f… Patrick OShaughnessy

Paul and I want to build a world where cells can cure everything. Check out the receptor we made to overcome failures in CAR T cells.👇 We are engineering tools for next-gen cell therapies that treat cancer, autoimmunity, and beyond. If you are interested in joining us, DM me!

"Biology is the most powerful way to transform the physical world using AI." Very true. Immense untapped potential. Great read!

We show that generative AI + high-throughput wet lab experimentation are a powerful combo that enable de novo antibody design. We validate hundreds of AI-designed antibodies and open source this data: Paper: biorxiv.org/content/10.110… Data: github.com/AbSciBio/unloc…

Ion gradients; the OG information transmitters. What other mysteries do they hold?

Bispecifics axial.substack.com/p/axial-discov… “There are more different ways to make bispecific antibodies than flavors of Ben & Jerry’s ice cream." - Paul Carter Genentech

Michel Levin and Jamie Davies examine the transition from cell-level synthetic biology to multicellular synthetic morphology. This agential bioengineering approach could transform regenerative medicine and robotics Michael Levin go.nature.com/3QMQPCd

BioGPT, a domain-specific generative model pre-trained on large-scale biomedical literature, has achieved human parity, outperformed other general and scientific LLMs, and could empower biologists in various scenarios of scientific discovery. Learn more: msft.it/6014eAnLq

We've built a transformational #multiplexed drug discovery platform at Manifold Bio and our first few programs only scratch the surface of what it can do. Looking for a generative thinker to sit at the interface of R&D and BD to map new programs from POC through development.

Michael Chavez spent 3 years with us as Fifty Years' Synthetic Biologist before co-founding Enoda, which transforms cells into cures. Michael is INCREDIBLE. He's now hiring Enoda's first scientist! Rare opportunity to join an exciting bio startup on Day 1. linkedin.com/jobs/view/3455…

Dandelion pollen of ideas, Xerox PARC edition

BIG NEWS: Dojo House, the first biotech hacker house, is coming back to Boston for a second summer! 🗓️June 1st - August 11th (10 weeks) 📍Cambridge, MA 🧬 Biotech education & training 🎤 End-of-summer pitch night We're looking for 8 undergrads to join us, learn more below! 👇

I have a new Substack. The first one's about the most interesting opinions I've read on A.I. Try not to die from surprise. But at this point it's much weirder NOT to talk about it. whatsimportant.substack.com/p/artificial-i…

We Robot 2023 will take place in Boston Boston University School of Law Sept. 29-30 with a pre-conference at the M.I.T. MIT Media Lab. Submissions now open! Abstracts due March. 27th. bu.edu/law/engagement… #werobot2023 #itsgoingtobeawesome

Great read. Quality of data obviously critical, but the *uniqueness* described here is still underutilized across bio (imo anyway)!

Flagship unveils Metaphore Biotechnologies, a company pioneering the use of machine learning and molecular mimicry to create transformative therapeutics. Read more: bit.ly/3O832lA #FlagshipFounded Metaphore Biotechnologies

We are excited to announce a collaboration with Novo Nordisk and Flagship Pioneering's Pioneering Medicines to develop long-acting, multi-targeting medicines in the GLP-1R biology space. Read more: metaphorebio.com/news/flagship-… #FlagshipFounded

Frequency is back for Summer 2024. Apply by July 2! If you are interested in starting biotech companies, this is a 1 week, part time, crash course experience in all aspects of early stage company building. Alumni have started leading companies + joined top VC firms worldwide.

Fantastic program! Highly recommend taking a look at all the things Tony (and Pillar) is up to!