Amazing insights by Kesavardan S at #Immunocon2024 on how bats have evolved to become viral reservoirs by efficiently limiting inflammation during infections. IISc Bangalore #Batbiology #virology #batimmunity

Reservoir host species (birds and bats) often stay asymptomatic compared to humans during viral infections. Regulation of multimodal cell death pathway (PANoptosis) in bats and birds contributes to their viral tolerance. #Anantika Kesavardan S mdpi.com/1999-4915/16/1…

So Happy to share our lab's latest study, Uncovering how RNA viruses modulate viral RHIM proteins in bats and humans, resulting in activation of different cell death pathways 🦇🧬🦠. Congratulations to the team.Kesavardan S Sanchita Mishra Disha jain cell.com/iscience/fullt…

Pleased to share our recent review article on the emerging biology of Z-nucleic acids (Z-RNA/Z-DNA) and their sensing by #ZBP1 in virus infections, cellular physiology and disease pathogenesis. Great work by Sanchita Mishra &AyushiAminDey. onlinelibrary.wiley.com/doi/full/10.11…

How do bats tolerate deadly viruses without severe disease? In our latest review, we uncover the fascinating immune adaptations that help bats regulate inflammation and cell death—allowing them to host viruses like SARS-CoV, Nipah, and Ebola. Read the full article here 🔽

Check out our latest discussion on what makes bats the ultimate virus hosts 🦇🦇

Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s? We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.

🚨New paper with Xavier Lab Science Magazine on the critical role of 🔁neuroimmune crosstalk in immune defense in the gut! Gene Lay Institute of Immunology & Inflammation Mass General Brigham Research @HarvardMed @BroadInstitute science.org/doi/10.1126/sc…