In a first, scientists isolated heteromeric amyloid filaments from the brain. TDP-43 and Annexin A11 team up to form filaments in a type of frontotemporal lobar degeneration. MRC Laboratory of Molecular Biology Penn ow.ly/WwYJ50Sw8ar

Our cryoET study of Alzheimer's pathology is out! 🧠 In situ amyloid to 8.7 Å, mysterious plaque constituents & the intriguing in-tissue organisations of Aβ and tau filaments! Joshua Jenkins Nayab Fatima Tom O'Sullivan René Frank & team 🤩 #teamtomo nature.com/articles/s4158…

👋🏻 I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published in nature. 🥳 This unassuming little helix–turn–helix protein packs quite the punch! 🧶👇🏻 rdcu.be/dNl45

Congratulations to alumni Maria Grazia Spillantini (SpillantiniLab) and Benjamin Podbilewicz (Benjamin Podbilewicz) who have been elected to EMBO! #LMBAlumni LMB PhD Programme MRC-LMB Cell Biology embo.org/press-releases…

Looking forward to this!

Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headlines in this video: cell.com/cell/fulltext/…

Would you like to work in the MRC-LMB EM facility? mrc.tal.net/vx/mobile-0/ap…

Today 60 years ago Tony Crowther started at the MRC Laboratory of Molecular Biology! This afternoon, we celebrated this incredible feat. Tony's positivity has been and continues to be a great inspiration, and the fact he still comes to the lab every other week or so is a testimony to its fantastic vibe.

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Delighted to share our paper on the selective degradation of aggregated tau. JoJo Benn and Shi Cheng used nanobodies against tau, and fused them to the catalytic RING domain of clustering-activated E3 ligase TRIM21 to create R-Nb science.org/doi/10.1126/sc…

Unprecedented heteromeric amyloid structure in neurodegenerative disease. Diana Arseni & Benjamin Ryskeldi-Falcon unexpectedly find that annexin A11 assembles alongside TDP-43 in frontotemporal lobar degeneration with TDP-43 pathology Type C. Read more: www2.mrc-lmb.cam.ac.uk/unprecedented-… #LMBResearch

Hey #teamtomo!Our 1st❄️🔬work Human Technopole is finally out!🥳nature.com/articles/s4159… Serialized On-grid Lift-In Sectioning for Tomography(SOLIST) enables a biopsy at the nanoscale and high-res❄️STA from🧍‍♀️organoids and🐭liver, brain and heart tissue!Thread by Gaia Perone below!

The UK DRI's William McEwan & Leo James' Lab (MRC Laboratory of Molecular Biology) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21. The treatment improved symptoms of neurodegeneration in mice👉buff.ly/47ogpFG

Honoured to join this community and looking forward to making new connections, thank you The Vallee Foundation!

This was an excellent meeting discussing the impact of new technologies on ALS research. A huge thank you to the organisers for putting it all together!

We have a PhD position available in our group at the MRC Laboratory of Molecular Biology to study the molecular mechanisms of neurodegenerative diseases. More info below and feel free to get in contact! www2.mrc-lmb.cam.ac.uk/students/inter…