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The NKI is looking for outstanding candidates who want to become the new generation of ambitious #PhD students in a lively international research community. Check the website to learn about our #PhDprogram in #MolecularLifeSciences & #CancerBiology ➡️ bit.ly/3Ay8XJL

We wrote a review about sequencing-based techniques for studying DNA double-strand break repair. Free download until 15 Oct: authors.elsevier.com/a/1feiv5aisDQM…

Two weeks left to apply for the NKI PhD program! Deadline Sept 30th. nki.nl/careers-study/…

Our paper on the impact of CTCF and cohesin on genome - lamina interactions is out: genomebiology.biomedcentral.com/articles/10.11…. Our revised manuscript was parked on the editor/reviewer's desk for 24 weeks, but in the end it got accepted. Sometimes the publishing system does not work so well...

We identified dozens of DNA double-strand break repair proteins that modulate MMEJ:NHEJ balance depending on the local chromatin context: doi.org/10.1101/2022.1…

We have a position available for a Technician. Would you like to work on new genomics techniques and do you like to work in a team? See nki.nl/research/resea… for info about our research. Please send your application letter + CV to [email protected].

Our lab has a postdoc position available! Several possible projects in functional genomics of gene regulation, using exciting new approaches. Computional, wet-lab or both. If you are interested: contact us at [email protected].

NKI PhD program, this year with several positions focused on chromosome biology and gene regulation, is open for applications. nki.nl/careers-study/…

Hey scientist! Are you an aspiring #PhD student looking to take your research to the next level in a dynamic institute and city? Then look no further and apply for our #PhDprogram ➡️ bit.ly/44iOcOc

New preprint from our lab: Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements. biorxiv.org/content/10.110…

New preprint from our lab: E-E-P massively parallel reporter assay to understand how signals from *two* enhancers are integrated by promoters: doi.org/10.1101/2023.0…

We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-dependent manner. With impact on cancer genomes. Paper is finally out: nature.com/articles/s4146…

... and we used our platform of 19 chromatin-integrated pathway reporters to probe context-dependent effects of epigenetic drugs on Cas9 editing: academic.oup.com/nar/advance-ar…

The first preprint of our PERICODE consortium: MPRA-trained deep learning provides insight into the regulatory logic of promoters and transcription factors. biorxiv.org/cgi/content/sh…

We generated a collection of new and optimised (and multiplexable) TF reporters for human and mouse cells: biorxiv.org/content/10.110…

New preprint by our lab -- Revealing the functional landscape of a large genomic locus by highly multiplexed local hopping of a reporter: biorxiv.org/content/10.110…. Even a 'simple' genomic locus such as the mouse Sox2 locus still holds surprises...

We are leaving Twitter/X and we will instead post our lab's news on linkedin.com/groups/1309164…. Thanks for following us, we hope to see you there!

If you did not abandon this platform yet (it really is time to go!): In addition to LinkedIn, you can now also find us on Bluesky: @basvansteensellab.bsky.social.