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Impact of cytomegalovirus (CMV) seroconversion pre‐allogeneic hematopoietic cell transplantation on posttransplant outcomes - Sayyed - European Journal of Haematology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/ej…

In a phase 1b–2 study, a five-agent treatment aimed at tumor survival pathways in relapsed and refractory diffuse large B-cell lymphoma was associated with a complete response in 38% of the patients. Read the full study results: nej.md/3xyDZSC

Now online 👇🏼 Letermovir as SECONDARY prophylaxis of CMV after allogeneic hematopoietic cell transplantation. onlinelibrary.wiley.com/doi/10.1111/ej… #MedTwitter Hans Messner Allogeneic BMT Program Arjun D. Law Ivan Pasic Princess Margaret Cancer Centre

Bleomycin cautions use in elderly patients with HL.

The first study to evaluate treosulfan with ATG and PTCY reveals treosulfan's efficacy and safety in stem cell transplantation. Treo-based conditioning shows better overall survival versus busulfan in #mds patients. Read more: ow.ly/1tzN50Sx6gW

Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML ashpublications.org/blood/article-… Key takeaways Adverse risk CG, WT1, DNMT3A, FLT3ITD were associated with high rate of MRD+ by PCR & ⬆️ relapses In spite of high risk molecular features, MRD- overcome bad

Now for what you've all been waiting for: one of Matthew Ho's beautiful algorithms. Here is everything all together!

Updated thrombocytopenia also PEARLS - many drugs can cause DITP; immune causes typically 1-2 wks after exposure; nonimmune nadir 7-10d; plt recovery after 4-5 half-live - + anemia: r/o MAHA - + clots: HIT, APS, PNH, TMA, DIC, HELLP, VITT, VEXAS - Clinical context important

Updates to Pancytopenia inspired by @lukasronnerMD heme conference. Stole parts of it from the amazing William Aird and The Blood Project Biggest takeaway: most important test is the "Vibes" test (i.e., take a good history and exam and let that guide workup). Erin Aakhus

🩸 Approach to Polycythemia onlinelibrary.wiley.com/doi/epdf/10.10…

Approach to thrombocytosis

Updated Approach to Erythrocytosis

How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients ow.ly/BsEl50TgBw2 #HowITreat #transplantation

Harrison is one of the most amazing teaching books ever produced A short thread on brilliant educational algorithms in internal medicine

Congratulations Arjun D. Law

Clonal Monocytosis of Renal Significance #CMRS pubmed.ncbi.nlm.nih.gov/39299498/ #Lysozyme #EMH #ICGN #Monocytes #MPN-G #CMML #CMUS #CCMUS Priya Alexander, MD Nelson Leung Mayo Clinic Comprehensive Cancer Center Mayo Clinic Nephrology

Just out: mSMART Updated guidelines for newly diagnosed myeloma. mSMART.org Main Change: We recommend quadruplets as initial therapy for all newly diagnosed patients who are not frail. Update based on IMROZ, CEPHEUS, and BENEFIT RCT data. Mayo Myeloma

Fractures are common within 18 months following first-line R-CHOP in older patients with diffuse large B-cell lymphoma [Sep 22, 2020] Booth et al. Toby Eyre Blood Advances ow.ly/GIxQ50BHLHT #lymsm #BoneHealth #SuppOnc #geriheme

Does speeding up neutrophil engraftment truly make a difference? Check out our study on the impact of G-CSF post Allo-HCT journals.lww.com/transplantatio… Ayman Sayyed Hans Messner Allogeneic BMT Program

Prolonged length of stay in high-risk patients undergoing allogeneic stem cell transplantation: a call to action for addressing healthcare challenges | Bone Marrow Transplantation nature.com/articles/s4140…