Quantifying the stochastic component of epigenetic aging nature.com/articles/s4358…

Morphological features of the skin can predict aging with a mean absolute error comparable to state-of-the-art epigenetic clocks. Download our paper here: biorxiv.org/content/10.110…

Congrats Julia Magdalena Majewska Amit Agrawal . Thanks Uri Alon for great collaboration.

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells nature.com/articles/s4155…

Immunotherapy as an anti-aging treatment? Valery Krizhanovsky we show that immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! Amit Agrawal Uri Alon IdoAmitLab Weizmann Institute nature.com/articles/s4155…

📑: Julia Magdalena Majewska Amit Agrawal et al fr/Valery Krizhanovsky show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. nature.com/articles/s4155…

Last sunset before we kick off #SCG24! Truly excited to engage with the global single cell family. Wondering about what Harreman, Nativ and CytoVI mean? Come by our posters!

The power of Longitudinal studies for comprehensive view of physiology and pathology. How pregnancy changes our body? Can systemic inflammaging precedes cancer diagnosis? Check out below.. science.org/doi/10.1126/sc… doi.org/10.1073/pnas.2… Uri Alon @Mark M Davis

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.

We live once, but we don't have to die once.

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

How to identify persistent senescent cell with increased resistance to apoptosis? Check our latest preprint with spotlight on cell surface v-type ATPase ATP6V1B2.. @NatalyFreizus Valery Krizhanovsky Uri Alon biorxiv.org/content/10.110…