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Glad to share our new preprint on promoter escape by mammalian Pol II! We captured five transcription intermediates (de novo initiated from the PIC) and visualized the key steps where the initially transcribing complex (ITC) transitions into an elongation complex (EC).

Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template Published in nature nature.com/articles/s4158… Many thanks to my mentor Patrick Cramer Patrick Cramer for unwavering support

The final version of our work on initiation-elongation transition by mammalian Pol II is now online! We visualized key transition steps during initiation and early elongation. Many thanks to Patrick Patrick Cramer, Christian Christian Dienemann, Elisa Elisa Oberbeckmann and the Cramer lab!

Es geht wieder los: Die Aufgaben zur 1. Runde der IBO 2025 stehen für euch bereit! Diesmal geht es um Honigbienen🐝, die Backhefe S. cerevisiae in der Biotechnologie🧑‍🔬, Organspende🫀 und das menschliche Gedächtnis 🧠. Klingt spannend? Dann erfahrt mehr auf biologieolympiade.info

I’m happy to announce that I was appointed a junior professor at Universitätsmedizin Göttingen (UMG). Many thanks to everyone who supported me during my journey, especially Patrick Cramer and his team (Michael Lidschreiber, Christian Dienemann & K. Zumer), but also all past and present colleagues and collaborators.

Extremely honoured to receive the Otto Hahn Medal and the Otto Hahn Award today from the Max Planck Society Max Planck Society ! An amazing recognition of my work and the scientific environment and support in the Schuh Lab at the MPI for Multidisciplinary Sciences ! 🔬❤️

Deadly kiss of polymerases: How Influenza polymerase cleaves capped nascent RNA from host Pol II to start its own transcription. Preprint from Alexander Rotsch et al. with Steven Cusack‘s lab EMBL Grenoble. biorxiv.org/content/10.110…

Congratulations to Florian Kabinger and Alexander Rotsch for passing their PhD defenses today with distinction. Florian Kabinger Alexander Rotsch

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. Max Planck Institute of Biochemistry (MPIB) 👇👇👇

The pro-Trump "free speech enthusiast" owner of this platform decided to just delete the viral anti-Trump ad I posted I few days ago (and replaced it with a "This Post was deleted by the Post author" message). So here it is again Elon, enjoy!

We had a great time at our lab retreat at the Harnack House together with the Marieke Oudelaar lab and Patrick Cramer. Exciting talks from our guest speakers Stephan Hamperl, Edda Schulz and Stefanie Grosswendt. Thanks for coming!

So proud of Dr Aitu @zhnbkv_ai!! Congratulations on her fantastic PhD 🎉

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/sh… (1/6)🧵

Perfect holiday reading! Dive into the exciting work on the molecular mechanism of co-transcriptional H3K36me3 by SETD2 from our fantastic postdoc James Walshe & Moritz Ochmann! biorxiv.org/content/10.110…. Also check out the great related work by Lucas Farnung & Kurumizaka Lab.

Structure of the Nipah virus polymerase complex Jonathan Grimes and collaborators embopress.org/doi/full/10.10…