Alex Lercher (@alex_lercher) 's Twitter Profile
Alex Lercher

@alex_lercher

Immunologist | HFSP Postdoctoral Fellow @RiceLaboratory | PhD @bergthalerlab | opinions are my own. find me on @alercher.bsky.social

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calendar_today29-12-2013 23:46:38

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Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Great guide on the different flavors of ๐™ก๐™ช๐™ฃ๐™œ ๐™ข๐™–๐™˜๐™ง๐™ค๐™ฅ๐™๐™–๐™œ๐™š๐™จ โ€“ their niches, what transcriptional programs define them, how they are maintained and their principal functions in homeostasis and lung inflammation cell.com/immunity/fulltโ€ฆ Immunity Claudia Jakubzick

Great guide on the different flavors of ๐™ก๐™ช๐™ฃ๐™œ ๐™ข๐™–๐™˜๐™ง๐™ค๐™ฅ๐™๐™–๐™œ๐™š๐™จ โ€“ their niches, what transcriptional programs define them, how they are maintained and their principal functions in homeostasis and lung inflammation

cell.com/immunity/fulltโ€ฆ

<a href="/ImmunityCP/">Immunity</a> <a href="/claudjak/">Claudia Jakubzick</a>
Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Great review by Julia S. Brunner and Lydia Finley on how ๐™ข๐™š๐™ฉ๐™–๐™—๐™ค๐™ก๐™ž๐™˜ ๐™ฅ๐™ง๐™ค๐™œ๐™ง๐™–๐™ข๐™จ influence basic decision points of cell identity like self-renewal vs proliferation โ€“ makes me want to give my current project a metabolic twist! Nature Reviews Endocrinology rdcu.be/c0DRI

Great review by <a href="/jules_stef/">Julia S. Brunner</a> and <a href="/lydfinley/">Lydia Finley</a> on how ๐™ข๐™š๐™ฉ๐™–๐™—๐™ค๐™ก๐™ž๐™˜ ๐™ฅ๐™ง๐™ค๐™œ๐™ง๐™–๐™ข๐™จ influence basic decision points of cell identity like self-renewal vs proliferation โ€“ makes me want to give my current project a metabolic twist!

<a href="/NatureRevEndo/">Nature Reviews Endocrinology</a>

rdcu.be/c0DRI
Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Sub-cutaneous BCG vaccination induces ๐™ž๐™ฃ๐™ฃ๐™–๐™ฉ๐™š ๐™ž๐™ข๐™ข๐™ช๐™ฃ๐™š ๐™ข๐™š๐™ข๐™ค๐™ง๐™ฎ in alveolar macrophages via altered metabolite output of the gut microbiota. In fact, dietary supplementation of butyrate is sufficient! Nature Immunology nature.com/articles/s4159โ€ฆ

Sub-cutaneous BCG vaccination induces ๐™ž๐™ฃ๐™ฃ๐™–๐™ฉ๐™š ๐™ž๐™ข๐™ข๐™ช๐™ฃ๐™š ๐™ข๐™š๐™ข๐™ค๐™ง๐™ฎ in alveolar macrophages via altered metabolite output of the gut microbiota.

In fact, dietary supplementation of butyrate is sufficient!

<a href="/NatImmunol/">Nature Immunology</a>

nature.com/articles/s4159โ€ฆ
Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Had a great time presenting our work on antiviral innate immune memory! Thanks to HFSP for the opportunity and support of this project! Link to the initial version of the manuscript: biorxiv.org/content/10.110โ€ฆ

Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Our article on antiviral innate immune memory and alveolar macrophages made the cover of Immunity Check out the full article here: shorturl.at/tArb0

Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases? shorturl.at/SZ1Ww Cell Stem Cell Eric Pietras Taylor Scott Mills

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww

<a href="/CellStemCell/">Cell Stem Cell</a> <a href="/pietras_eric/">Eric Pietras</a> <a href="/Taylor_S_Mills/">Taylor Scott Mills</a>
Alex Lercher (@alex_lercher) 's Twitter Profile Photo

If you are an auditory person โ€“ TWIV discussed our recent paper on innate immune memory in sequential respiratory viral infections. Paper review starts at 37:00, more general discussion and broader implications at 1:10:00. open.spotify.com/episode/777wxTโ€ฆ MicrobeTV Immunity

Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Great Spotlight by Prof. Akiko Iwasaki and Sasha Tabachnikova ๐Ÿ‡บ๐Ÿ‡ฆ on our recent publication in Immunity, where we studied antiviral innate immune memory in alveolar macrophages in the context of respiratory viral infections! cell.com/trends/immunolโ€ฆ

Alex Lercher (@alex_lercher) 's Twitter Profile Photo

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine โ€“ great therapeutic potential! Two studies in nature by Michael Fischbach and Belkaid Lab tinyurl.com/5yahn47t tinyurl.com/4n4btxap

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine โ€“ great therapeutic potential!

Two studies in <a href="/Nature/">nature</a>  by <a href="/mfgrp/">Michael Fischbach</a> and <a href="/BelkaidLab/">Belkaid Lab</a>

tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
Alex Lercher (@alex_lercher) 's Twitter Profile Photo

Location, infection history, antigen persistence shape the tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases. High/low antigen immunogenicity may add another layer... Immunity tinyurl.com/49dkc3j7

Location, infection history, antigen persistence shape the  tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases.
High/low antigen immunogenicity may add another layer...

<a href="/ImmunityCP/">Immunity</a> 

tinyurl.com/49dkc3j7