Really nice review on location-selective GPCR signaling in neurons by Manoj Puthenveedu (he/him) Lab! sciencedirect.com/science/articl…

There is an upside! elifesciences.org/articles/81075?

We report 57 multi-GPCR proteins, identified with a sequence-based search, and then used #AlphaFold to predict their 3D structures. Here is an example: the predicted structure (with 2 7TMs) of A0A3L7HXX2from Cricetidae (a rodent)🐿️(pLDDT 81.5).(4/11)

Our paper by Subhi Marwari and Cody Kowalski is out today in British Journal of Pharmacology (BJP). We find that pharmacological blockade of Gq/11 suppresses activity of DRG neurons, their inhibition by opioids and has analgesic effects in mice. bpspubs.onlinelibrary.wiley.com/doi/10.1111/bp…

Check out our new paper in led by Gissell A Sanchez in a team effort from the Smrcka Lab, Susie L Ingram and emily j labs. A nice complement to the recent work by Kirill Martemyanov Lab on Gq targeting and opioid antinociception. molpharm.aspetjournals.org/content/early/….

Excited to share our new paper out in nature , led by our postdoc Yonghoon Kwon. We report the discovery of spatially organized GPCR-mediated ERK signaling using biosensors. #GPCR #ERK #biosensor #imaging #CellSignaling 1/6 nature.com/articles/s4158…

Congratulations to Umich Pharmacology 2022 Outstanding Alumni Speaker, Dr. Ezra Lowe, and his graduate mentor, Dr. Yoichi Osawa!

I’m honored to be recognized for my most recent publication 😌Thank you to Smrcka Lab for nominating my work to be highlighted 🙏🏻🙌🏻

Morales, Smrcka, Anantharam et al UToledo Medicine show that PACAP, an important neurotransmitter at the splanchnic-chromaffin cell synapse, operates through a pathway involving Gαs, PLCε, & L-type calcium channels bit.ly/3G7O9v1 #CellularPhysiology #IntercellularSignaling

Very excited to share the first paper from my postdoc in the MacKinnon lab as a preprint. We’re studying PLCb enzymes, which cleave PIP2 to produce IP3 and DAG downstream of GPCR activation. (1/4) biorxiv.org/cgi/content/sh…

Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis [Articles] ift.tt/z4nS6x7

Our latest Research News: Morales et al. (bit.ly/3G7O9v1) reveal how the neurotransmitter PACAP induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine. bit.ly/3ZSckW2 Smrcka Lab

Congratulations to Tyler Lefevre who is now a Ph.D.!

I’ve had the pleasure of chairing the Pharmacology in Color symposium with Manoj Puthenveedu (he/him) at the ASPET conference this year. I’m grateful that I’ve been able to be in the planning team Umich Pharmacology and branch it out to ASPET .

Wei did a wonderful job delivering her talk on the opposing effects of beta 1 and beta 2 signaling in cardiac hypertrophy. #ASPET2023

Congratulations to this year's ASPET mol pharm postdoc competition winners! Ashley Nilson, Francesco De Pascali, and G. Aditya Kumar #ASPET2023 #molpharm #pharmacology

The crew at #ASPET2023

Congratulations to Wenhui Wei who won 1st place in the Cardiovascular Showcase Trainee Competition ASPET ! #ASPET2023

Congrats to Kennedy Outlaw!! She won 1st place Mol Pharm undergrad poster at ASPET 2023!!!!

It was great meeting Dr. Namandje Bumpus @BumpusLab , the Chief Scientist of the US FDA and the current president of ASPET today during #ASPET2023. Read an article in @trendsinpharma discussing one of her works. cell.com/trends/pharmac…