SKYCovione, a COVID-19 vaccine developed by SKbioscience in South Korea with computational protein engineering technology from Institute for Protein Design @uwbiochemistry UW Medicine today received World Health Organization (WHO) emergency use listing. tinyurl.com/4c9shve3

I'm very excited to announce that I'll be starting my lab at ISTAustria near Vienna this summer! The Bravo lab will be using enzyme kinetics and cryo-EM to study bacterial immunity. Read more here: bravo-lab.org

Finally our work on designing pH responsive antibody nanoparticles capable of disassembling at ~tunable~ pH, packaging and releasing cargo, and targeting specific cell surface receptors is out in NatureStructMolBiol! nature.com/articles/s4159…

Age-dependent RSV-specific humoral profiles, demonstrating a profound window of immune vulnerability in infants, and functional immune correlates of protection against RSV disease Immunity Galit Alter Nadège Nziza cell.com/immunity/fullt…

🎉Congratulations to Assistant Professor @ArbelHarpak for being named a 2024 Pew Biomedical Scholar by The Pew Trusts to explore the drivers of sex differences within both humans and animals. pewtrusts.org/en/about/news-… Integrative Biology

Very excited to share this story about two substitutions in a sarbecovirus spike that enhance infectivity by increasing RBD availability. My first cryoEM structure was of the RsSHC014-CoV spike protein and is included in this manuscript! biorxiv.org/content/10.110…

Our #cryoET study of #RSV is out in Nature Communications!! rdcu.be/dNKAk Using #subtomogram averaging we show the matrix protein packs as a helical-like lattice. The Fusion gp arranges as F-trimer pairs & correlate w/the M lattice. Great work Bryan Sibert & coauthors!❄️🔬🦠

Excited to share our new study @nature led by The PhD Program in Virology at HMS grad student Wanyu wy that explores shifted receptor usage by a unique “submerging” arbovirus, western equine encephalitis virus (WEEV).🤩 nature.com/articles/s4158…

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer nature.com/articles/s4146…

Now this paper is published in its final form. Thanks to Daniel and Ece for their hard work, and to our collaborators Bill Wimley William Wimley and Elena Pasquale.

Everything you ever wanted know about antibody feedback and immunological imprinting* …*but were afraid to ask. Will Voss Jason Lavinder cell.com/cell-reports-m…

Have questions about preparing your data and submitting your structure to the PDB? Register for the Sept 12 Virtual Office Hour: Streamlining PDB Deposition rcsb.org/news/feature/6…

We are excited to share the review we have written to explain the concept of signaling bias to a broad audience.

These substitutions also provide enhanced thermostability and cellular expression, allowing complete structural characterization of the closed prefusion conformation via cryo-EM (kudos to Ling Zhou, Cory Acreman, and Jason McLellan) (PDB ID: 8VAO rcsb.org/structure/8VAO)

Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses dlvr.it/TCTcqz

#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge. This collaborative project was led by Cara Chao and is out now on bioRxiv: biorxiv.org/content/10.110…

There’s a new big fish record in Lady Bird Lake. 🎣 trib.al/0X3G1qu

After pandemic delays/starting residency, I am THRILLED to finally get this paper out 🤗 a combo of my favorite things: pretty protein/antibody structures and a live Nipah experiment 🥰 (and working with Sope Oguntuyo) enjoy our latest w/ mAb92 🦠 #nipah journals.asm.org/doi/10.1128/jv…

Thank you to each of you who came to be our guest at the Award for Innovation in Healthcare and Bioscience. Handshakes, hugs, a shared meal, laughter and learning from an expert in his field, Jason McLellan It was a beautiful evening.