Excited to share our latest work published today Cancer Discovery: Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance aacrjournals.org/cancerdiscover… Jian Xu Children’s Research Institute at UT Southwestern @UTSWNews

Preclinical cell models developed by Jian Xu uncovered a new class of mutations responsible for resistance to targeted therapies in acute myeloid leukemia patients w/ mutations in their IDH genes. Learn more about the study published in Cancer Discovery below. cri.utsw.edu/scientists-dis…

Now online in Cancer Discovery: Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance Junhua Lyu Jian Xu Children’s Research Institute at UT Southwestern @UTSWNews aacrjournals.org/cancerdiscover…

Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance, by Junhua Lyu, Jian Xu et al. bit.ly/3s30zwz Children’s Research Institute at UT Southwestern

ICYMI in Cancer Discovery by #ASH22 speaker Jian Xu: Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance aacrjournals.org/cancerdiscover… Junhua Lyu Children’s Research Institute at UT Southwestern

If you want to learn more about CRISPR base-edited isogenic IDH-mut leukemia cells, Junhua Lyu is presenting his latest findings #ASH22 Jian Xu Children’s Research Institute at UT Southwestern