I'm going to keep saying this until someone proves me otherwise: AlphaFold(2, 3, 10000, whatever) or any structure prediction tool will not generalize to protein conformations if its training is optimized to "ground truth" structures in the PDB! Crystallized or cryo-EM structures

A structural learning method to uncover how information between single cells flows nature.com/articles/s4159… #journals #feedly

Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome biorxiv.org/content/10.110…

NERD-seq: a novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs genomebiology.biomedcentral.com/articles/10.11…

Microtubules traffic jams

Latest from us. Racial disparities are still pronounced in IEIs. We posit that we need to work on better referral system! Thank you O'Jay Stewart for starting and Patrick O’Conell for finishing the study. Mount Sinai Genetics Columbia Children's Health link.springer.com/10.1007/s10875…

Interested in working on RNA processing and degradation? Come join us! My lab is recruiting at all levels!

Omg, our paper was selected for the Nature Immunology cover with the amazing "Black Hole Thymus" illustration by DrawImpacts

⁦⁦It’s a wrap! ⁦Thanks to Sir Marc Feldmann and Dame Fiona Powrie for the hospitality! ⁦Kennedy Institute of Rheumatology⁩ Trinity College University of Oxford #biologics #translational #neuroimmune

I'm excited to share that, in just a week, I'll be presenting our work on hematopoietic aging and cancer from the lab of Miriam Merad, MD, PhD Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Lipschultz Precision Immunology Institute at #CICON24 Cancer Research Institute. Looking forward to seeing everyone there!

The large prefrontal cortex in humans provides evolutionary and cognitive advantages over non-human primates — but there’s a cost. go.nature.com/3TeTUgB

This was my first experience, and I’m thrilled with the outcome! I accomplished this while still in my final year of medical school. I’m committed to working even harder for greater achievements ahead

Still time to register for #SITC Summit on Intralesional #Immunotherapy on Thursday, Sept. 19! @ go.sitcancer.org/3JkaR3S Summit Organizers Joshua Brody, MD Mount Sinai Health System Tanja de Gruijl PhD Amsterdam UMC Howard Kaufman MD Matt Aurélien Marabelle MD, PhD Gustave Roussy

Neural Network Animation.

Happy Biologist Day! Image generated with Shakker.AI #Biologistday #happy #Science

After over 8 years at Icahn School of Medicine at Mount Sinai from postdoc to instructor to research assistant professor in AkbarianLab I will be joining a biotech startup in NYC in a few weeks. Leaving academia was a difficult decision, and I have a lot of mixed feelings about this career change 1/3

A mind-bogglingly old sex chromosome, in octopus! cool research from Andrew Kern lab, with great context and comments from Rebekah Rogers Melissa A. Wilson Jessica Abbott 🙏

Nice paper that goes deep into the loose correlation between mRNA & protein abundances and does some sensible adjustments/featurizations of mRNA to make it a better predictor of protein. Also very handy numbers here (median 17 mRNA vs. 50k protein copies per cell)

Excited to see my PhD work with Andreas Beyer and Francisco Lopes now online! 🥳🪩 Huge thanks to Andreas and former lab mates for all the support ❤️ We looked at how gene-gene coordination changes with age in 8 human tissues (see🧵👇): nature.com/articles/s4358…

Thrilled to share our first study on aging from Miriam Merad, MD, PhD lab Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Lipschultz Precision Immunology Institute in which we demonstrate how aging promotes cancer. We show that: (1/n) science.org/doi/10.1126/sc…