Great vibes at our summer party with clinical & research fellows! We celebrated a year of success with culinary gems from all over the 🌎! Thank you all for the amazing work you do! The Hospital for Sick Children (SickKids) Developmental, Stem Cell & Cancer Biology Zani Lab Lina Antounians Kasra Khalaj, PhD, MSc Sam M. Han, MD Fabian Doktor Lorenzo Añez-Bustillos

Congratulations to Kasra Khalaj, PhD, MSc for receiving the Rosenkrantz award for the best basic science paper at the Section on Surgery of the American Academy of Pediatrics #AAP2023! Zani Lab The Hospital for Sick Children (SickKids) SickKids Foundation SickKids Developmental & Stem Cell Biology Program U of T Department of Surgery APSA Surgeons CAPS Surgeons EUROPEAN PAEDIATRIC SURGEONS’ ASSOCIATION

On the way back home after an inspiring two days at the International CDH Conference in Lille, France Kudos to Rebeca Figueira, George Biouss, Sam M. Han, MD, and Marianna Scuglia for their great presentations!! #PedSurg Zani Lab CDH UK CDH International The Hospital for Sick Children (SickKids) SickKids Foundation

Proud of the innovative work presented by Fabian Doktor and Elke Zani-Ruttenstock for the Zani Lab at #APSA24 in Phoenix, AZ. Grateful to the APSAFoundation for the support in the past through the Grosfeld scholarship! APSA Surgeons The Hospital for Sick Children (SickKids) CDH UK CDH International University of Toronto U of T Department of Surgery

Proud to share that our contribution on the understanding of brain damage in fetuses with CDH is out! Kudos to George Biouss et al for this important work! CDH UK CDH International The Hospital for Sick Children (SickKids) SickKids Developmental & Stem Cell Biology Program Just published in Scientific Reports: rdcu.be/dKJnF

Amazing Zani lab party! I feel proud to lead such a great team!! 21 members, all with sublime work ethics, superb talent, and an incredible drive for success!!! Thank you all!! Zani Lab SickKids Developmental & Stem Cell Biology Program Lina Antounians Fabian Doktor George Biouss Elke Zani-Ruttenstock Kasra Khalaj, PhD, MSc Rebeca Figueira

Delighted to share our latest paper on #EV therapy for #CDH published on Science Advances! Full access: science.org/doi/10.1126/sc… Great teamwork of Zani Lab and collaborators Brian Kalish, MD, Martin Post, Michael Wilson. Grateful for support from APSA Surgeons The Hospital for Sick Children (SickKids) CIHR

Magnificent work led by the two stellar scientists Lina Antounians and Rebeca Figueira finally published at Science Advances - happy to have been part of the team! Zani Lab SickKids Developmental & Stem Cell Biology Program University of Toronto U of T Department of Surgery DFG public | @[email protected] APSA Surgeons EUROPEAN PAEDIATRIC SURGEONS’ ASSOCIATION SickKids Foundation

Thrilled to announce our latest publication in Science Advances! This marks my 33rd paper, 28 of them being from the same amazing lab led by Augusto Zani. Grateful for the support and collaboration of our incredible team. Check it out open access: science.org/doi/10.1126/sc…

Researchers at The Hospital for Sick Children (SickKids) found that #extracellularvesicles from #amnioticfluid #stemcells improve lung development and reduce inflammation in congenital diaphragmatic hernia cases. This offers new hope for affected infants. exosome-rna.com/the-potential-…

Zani Lab Lina Antounians Kasra Khalaj, PhD, MSc Fabian Doktor Elke Zani-Ruttenstock Martin Lacher Brian Kalish, MD Developmental, Stem Cell & Cancer Biology

Inspiring JPS/MacLeod lecture by Dr Henri R. Ford, MD, MHA, FACS, FRCS(Eng), FAAP on inclusive excellence CAPS Surgeons in Halifax! Only by fostering a diverse, equitable, and inclusive culture we will enhance excellence and achieve better outcomes for patients and surgeons American College of Surgeons #DEI

Amniotic fluid derived EVs are potential biomarkers of neuroinflammation in babies with spina bifida! Great talk AAP National Conference & Exhibition by Lina Antounians from Zani Lab SickKids Developmental & Stem Cell Biology Program The Hospital for Sick Children (SickKids) U of T Department of Surgery in collaboration with Jose Luis Peiró, Dr. Marc Oria and foong yen lim Cincinnati Children's

Delighted to share our latest research on #EV based therapies for fetal pulmonary hypoplasia secondary to oligohydramnios published now at the Journal of Controlled Release! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… SickKids Foundation CIHR DFG public | @[email protected] EUROPEAN PAEDIATRIC SURGEONS’ ASSOCIATION APSA Surgeons J Controlled Release

Read our 2 most recent publications where we 1) explored the experimental sex-specific therapeutic potential of AFSC-EVs on fetal hypoplastic 🫁 and 2) review their mechanisms and translational potential SickKids Developmental & Stem Cell Biology Program APSA Surgeons EUROPEAN PAEDIATRIC SURGEONS’ ASSOCIATION DFG public | @[email protected] CIHR Zani Lab

Great presentation by Kas Khalaj #ASC2025 Basic Science plenary session in Las Vegas! Getting closer to clinical translation with #stemcell #EV therapy for #CDH babies Zani Lab! WashU Medicine Division of Pediatric Surgery WashU Medicine Department of Surgery CDH International CDH UK Society of University Surgeons (SUS) APSA Surgeons #SoMe4PedSurg jpedsurg

Great honor to have been awarded with the Ilse Krause Young Investigator Award from the German Society of Pediatric Surgery! This would not have been possible without the support of the entire lab and I'm grateful for the ongoing support of my mentors Augusto Zani Martin Lacher

Excited to share a job opening for a Postdoc Fellow studying #Extracellularvesicles as therapeutic tools for fetal/neonatal diseases Zani Lab WashU WashU Medicine Division of Pediatric Surgery WashU Medicine Department of Surgery: isev.mcjobboard.net/jobs/186446?ut… ISEV Student Network on EVs #SNEV #ISEV2025 ISEV-Journals #JEV #JExBio

Proud of the innovative work on #CDH research presented by Rebeca Figueira and Fabian Doktor from the Zani Lab at the APSA Surgeons meeting in Montreal! Pushing the envelope for this fragile population of babies! WashU Medicine Division of Pediatric Surgery WashU Medicine Department of Surgery CDH International CDH UK #apsa2025

Proud to see Fabian Doktor receive the 2025 EUPSA Young Investigator Award for his work on the pathogenesis of pulmonary hypoplasia in #CDH! A true testament to the dedication of our entire Zani Lab team! WashU Medicine Division of Pediatric Surgery WashU Medicine Department of Surgery The Hospital for Sick Children (SickKids) CDH UK CDH International