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Today (and every day) I remember my parents, Nina and Emmanuel, who spent their childhood hunted like prey in Europe for being born Jewish I also remember the many family members who did not survive. In a family tree I made in school, those murdered are marked with red lines 1/

Fantastic to have our paper "Deciphering cell states and genealogies of human hematopoiesis" published today in nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by Chen Weng in a wonderful collaboration with Jonathan Weissman's Lab! nature.com/articles/s4158…

Ecstatic to announce our lab’s new paper in Science Magazine in collaboration with Abdel-Wahab Lab and Nurix Therapeutics led by Skye Montoya, Jessie Bourcier (Jessie Bourcier), Mark Noviski and Hao Lu. Sylvester Comprehensive Cancer Center Memorial Sloan Kettering Cancer Center #science #biology #cancer science.org/doi/10.1126/sc…

Excited to announce our collaborative paper with Taylor Lab UM and Nurix Therapeutics out today in Science Magazine: science.org/doi/10.1126/sc…

Wonderful to have our paper 'Deciphering cell states and genealogies of human haematopoiesis' led by Chen Weng, in a great collaboration with Jonathan Weissman's Lab, published today in nature: nature.com/articles/s4158…

Excited to announce our paper out today in Molecular Cell discovering a novel splicing factor GPATCH8 and its requirement for pathologic splicing activity of mutant SF3B1. With Robert K. Bradley & Sergei Doulatov. Led by Salima Benbarche, Jose Mario Pineda, & Laura Baquero Galvis: cell.com/molecular-cell…

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

Targetable leukaemia dependency on noncanonical PI3Kγ signalling | Thrilled to share this work nature from the inimitable Qingyu Luo, with many in our lab Dana-Farber and great collaborators too. Shareable link: rdcu.be/dHkeI, journal: nature.com/articles/s4158…

"Tempora mutantur, et nos mutamur in illis". Ovid knew long ago that our somatic genomes evolve throughout life... Super excited to share our new paper on connecting clonal outgrowth in somatic evolution with epigenetic profiles nature Open here: rdcu.be/dHkeS 🪡

Happy to share the final version of our #GAGEseq published today Nature Genetics! The single-cell co-assay for #scHiC and #scRNA reveals 3D genome & gene expression interplay in mouse cortex (also integration w/ #MERFISH) and during human hematopoiesis. 1/3 nature.com/articles/s4158…

New paper! We provide a scRNA-seq pipeline for simultaneous gene expression and 3′UTR length analysis. We quantified 3′UTRs in 474 cell types and found that 3′UTR length provides information that is independent of gene expression. nature.com/articles/s4146…

Beyond proud to share my thesis work, out today in Cell! My deepest gratitude to my amazing co-authors, those who come before me whose beautiful work this is built upon, and my extraordinary advisor, Camilla Forsberg. Forsberg Lab cell.com/cell/fulltext/…

Our latest paper out Nature Genetics today. Even more mutated genes driving clonal expansions in blood as we age. Additional genes found in UKBIOBANK UKBIOBANK confirmed in >10,000 while genomes of blood cell colonies. Calico Wellcome Sanger Institute Cambridge Stem Cell Institute Mike Spencer Chapman

🥳new pre-print alert! VEXAS syndrome deciphered - From single-cell genotype-to-phenotype mapping aaaall the way to mechanism and therapeutic vulnerability discovery! biorxiv.org/content/10.110…

So excited and proud to see our work on VEXAS syndrome with Rebecca Murray is out in bioRxiv . Many thanks to Dan Landau , David Beck, Eirini Papapetrou, MD, PhD , Neal S.Young, pierre sujobert , Kosmider olivier , for this lovely collaboration and for making this work possible!

Fantastic tips on starting a #NewLab during today’s WashU Division of Physician-Scientists #CAPSiT seminar feat. Anna Nam Melissa Mavers Sudarshan Rajagopal

Congratulations, Len and Cecilia!! Grateful to have contributed to this wonderful study with our computational research assistant Chhiring Lama!

Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in Nature Genetics today. Huge congrats to lead author Samuel John Taylor! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also

Today is the day 🤩. Thrilled to share our nature paper on Th2 function, CAR-T, & 8-year remission!⁩! Huge team effort w/⁦Stephan Grupp MD PhD⁩ ⁦⁦Carl June⁩ ⁦MelenhorstLab⁩ ⁦Li Tang⁩, kudos to my postdoc ⁦Zhiliang⁩ nature.com/articles/s4158…

Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same clinical FFPE tissue slide, including mRNA, miRNA, snRNA, snoRNA, tRNA, etc, and splicing isoforms, genetic alterations (SNV, CNV, etc). Really a fun,