1. 🚨New preprint: tinyurl.com/tenk10k-causal. We explored causal effects of gene expression in immune cell types on complex traits and diseases by combining single-cell expression quantitative trait loci (sc-eQTL) mapping in 5M+ cells from 1,925 donors in TenK10K study and GWAS. 🧵

This TenK10K study offers the most comprehensive single-cell chromatin accessibility QTL (caQTL) resource to date 👉3.5M PBMCs from 1,042 donors 👉243,273 caQTLs for 28 immune cell types 👉60% of them cell-specific 👉10-30% more colocalized signals for disease traits than eQTLs

TDAC-seq is a method for targeted chromatin accessibility profiling that uses cytidine deaminases and long-read sequencing to resolve the effects of CRISPR edits on single chromatin fibers. Brian Liau Heejin Roh Simon P. Shen Yan Hu nature.com/articles/s4159…

New online! Regulatory genomics at biobank scales bit.ly/3Vkg4yQ

Happy 25th anniversary to us! We're celebrating the journal's birthday with a bumper issue: go.nature.com/46CfyCB Read more in our editorial "Making sense of the regulatory genome": go.nature.com/4pqK2yX

Nice to see ultra-short term EU labeling applied for #singlecell RNA dynamics, revealing intergenic transcription. With 1h labeling coupled to ATAC and #CRISPR perturbations, we traced gene-regulatory dynamics during cell state transitions. Check out scFluent-seq and PerturbFate!

I’ll be giving a lightning talk on the TenK10K multiome project at #ASHG25 — 2:05 pm, Oct 17 in Room 205ABC. Come by poster 5001T if you’re interested in caQTL/eQTL mapping, cCREs, sc-multiomics integration, network inference & our TenK10K cohort! Happy to chat 1-on-1, plz DM me.

Can AI develop methods like a seasoned statistical geneticist? 🤔 In 8 hrs, our new method TusoAI improve two popular tools in genetics: scDRS (+40% power) & pgBoost (+11% enrichment). Preprint: arxiv.org/abs/2509.23986 Great work by Alistair Turcan with Kexin Huang Lei Li