Stem cell competition in human bone marrow. New study in Cell Stem Cell has found that resistance to inflammation gives mutated blood stem cells in human bone marrow a growth advantage over non-mutated stem cells. doi.org/10.1016/j.stem… Stephanie Xie @UHN_research paresh vyas

Mutant HSCs in human clonal haematopoiesis have an attenuated response to inflammation and ageing, which may give them a selective advantage.   Happy to share our new paper published in Cell Stem Cell: doi.org/10.1016/j.stem…   A thread below… /1

On the very 1st day of my PhD, I’m so excited to share my work exploring #CH #CHIP in the tumour microenvironment, out now as a preprint! CH clones that infiltrate the TME (CH-Tum) are linked w/ inflammation & poor clinical outcomes. Thread below! 1/ doi.org/10.1101/2024.0…

Delighted to share the first study from my group: "HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease", now under review. biorxiv.org/content/10.110…

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…

DeepSeek-R1 is great, but it still does not handle genomics yet :) 🚀 We’re thrilled to announce that IntegrAO (pronounced "integral") 🧬🔬—our new multi-omics integration framework—has been published in Nature Machine Intelligence! 📑 Paper: nature.com/articles/s4225… 💻 Code:

Online now concurrent with #AACR25 #hematooncology Minisymposium talk by Andy Zeng and Dr. John Dick team Princess Margaret Cancer Centre Research: Single-cell transcriptional mapping reveals genetic and hierarchy-based determinants of aberrant differentiation in AML. brnw.ch/21wShfF

Read the commentary: Putting AML Differentiation States on the BoneMarrowMap, by Jonas Berger and Livius Penter, online now concurrent with #AACR25. doi.org/10.1158/2643-3…

🚨 Breakthrough in #leukemia research! Dr. John Dick & team University Health Network have mapped how leukemia cells grow & change, uncovering 12 key patterns. This could lead to better diagnosis & more targeted treatments for AML patients. Read more➡️ uhnresearch.ca/news/decoding-… #CancerResearch

Understanding leukemia cell development in AML🩸 Our recent study revealed 12 cell states as AML cancer grow and develop. The findings, critical for AML classification and precision medicine, were reported by Drs. John Dick & Andy Zeng's team University Health Network. aacrjournals.org/bloodcancerdis…

Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!

Researchers have developed a map of normal hematopoietic cell differentiation and used it to examine how aberrant differentiation can lead to #AML, according to results presented by Andy Zeng, PhD: brnw.ch/21wShji #AACR25 Andy Zeng U of T News Princess Margaret Cancer Centre

A study published today in Nature Cancer from Princess Margaret Cancer Centre Research and St. Jude Research has mapped how human blood #StemCells create the blood lineage and uncovered why blood #cancer lineages can sometimes switch following #chemotherapy. 🔗Read more: uhnresearch.ca/news/investiga…

B-ALL is a disease of B-cell development, but where exactly does this process get derailed? For some patients, it’s earlier than you might expect and involves cellular states capable of both lymphoid and myeloid differentiation capacity! See Ilaria Iacobucci’s tweetorial here: