Excited to share my PhD work, out now in Science Magazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/sc…🧵(1/n)

It was a pleasure to be University of Oxford for the DPhil viva of (twitterless) Ava Van Ess Vincenzo DAngiolella. Many thanks to Ava and Christianson Lab for the fun discussion and excellent hospitality #dressdownmondays

Thrilled to see Liver Growth and Cancer Lab receive EASL emerging leader award. Thoroughly well deserved. EASLnews EASL Education MRC_HGU Institute of Genetics and Cancer The University of Edinburgh

Celebrate emerging talent! Nominate an exceptional young investigator for the Balfour Lecture Award and recognize their remarkable contributions to genetics (nominee has to have <10 years postdoc experience). genetics.org.uk/medals-and-pri…

Congratulations to our Director, Sara Wells, who has received an MBE in the King's Birthday Honours List 2024 for services to medical research! har.mrc.ac.uk/news/dr-sara-w…

This is wonderful news. It has been a pleasure to work with Sara through the MRC National Mouse Genetics Network. Congratulations!

1st #prerpint from the lab together with James Briscoe! biorxiv.org/content/10.110… Collaborative effort led by Shota Nakanoh & Despina Stamataki, with contributions from Lorena, Chiara Azzi, Alex Pokhilko, and help from proteomics (Crick & BI) + bioinformatic teams 🥂 (1/9)

🚨RTs please🚨 Apply to join our spatial hackathon, full details below and the call is looking for applicants across a range of computational, biological and clinical disciplines. 👇👇

What if I told you that I co-founded a startup in 1987 that obtained world-wide rights to GLP1 as a metabolic Rx, collaborated with Pfizer to show key activities, & abandoned it in 1990 when Pfizer lost interest? I tell the previously untold tale in an open access paper now up

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Thrilled to share that, together with my colleagues Centre for Targeted Protein Degradation and collaborators Boehringer Ingelheim, we report Science Magazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/sc…

🚨We are recruiting🚨. We have a UK Research and Innovation funded position available MRC_HGU for a Research Assistant working on Polycystic Liver Disease with Scott Waddell & @Mill_lab ! If you are interested in #organoids, #singlecell and disease modelling then apply! job: 11386 & link👇

Know it before you tag it!! 🏷️🧬

The big one is finally out!! In this paper, we set out to provide insight into the fundamental question; How do the individual cells from complex tissues regulate their proteomes? Brief summary of our findings 👇 biorxiv.org/content/10.110…