Do you often wonder what happens when bacteria use abortive and non-abortive anti-phage defenses at the same time? Then check out our new paper investigating this question, led by first authors Madison Williams (Maddie Williams (she/her)) and Lexi Reker! biorxiv.org/cgi/content/sh…

#vom2022 was great and all, but nothing gets close to this absolute unit: biorxiv.org/content/10.110… As close to the platonic form of a perfect lab debut paper as it gets, from alex meeske et al.

Hello Twitter. My NYC-based company, Archean Biologics (archeanbio.com), is working on a first-in-class universal influenza therapeutic and is looking for a research scientist with a background in protein biochemistry. If interested, please see tinyurl.com/ypjafxka

As Christmas approaches, you may enjoy this version of the Rebecca Lancefield Egg Nog recipe - delicious if made now. urldefense.proofpoint.com/v2/url?u=https…

Hello microbiologists! If you send us gDNA, you receive FASTQs in 2 weeks. $80 per bacterial genome, library prep included. For just a bit more $, we'll provide world-class bioinformatic analyses. Place an order directly at our website or ask how we can accelerate your research.

I’m happy to announce that I’m bringing my miniprep skills to the University of Rochester to start my own lab focused on CRISPR, HGT, and recombinases. This is where people usually say interested postdocs, students, RAs contact me, not going to rock the boat, so same! University of Rochester

Postdoctoral position available in my lab at Rockefeller University working on phage lysins. Only considering applicants currently in USA. PhD or MD. Proficiency in protein chemistry, molecular biology, and protein purification a must. Send application to [email protected]

Hi #CRISPR enthusiasts. #CRISPR2024 is being hosted in #NewZealand by Dipa Sashital, Gavin Knott, Bridget Watson and I. If you are thinking of attending, help us lock in a date by completing the following survey surveymonkey.co.uk/r/WYZM58Q. Pls RT @crispr2023

Hunter lab is hiring! We're looking for a postdoctoral associate to study the role of oral microbiota in CF-associated morbidities. Please RT! hr.myu.umn.edu/jobs/ext/354338

Our latest from andrew’s thesis on the role of cAMP in M. #tuberculosis drug resistance and fatty acid metabolism, now at eLife - the journal elifesciences.org/articles/81177 Thanks to our collaborators Tiago Beites Kyle Carter and Rachael Fieweger Ehrt & Schnappinger Labs rheelab Brian VanderVen

Thrilled to share this new paper from our lab. We show that Cas9 binds to hundreds of positions in bacterial genomes and can silence genes with as little as 4nt of complementarity between the guide RNA and the target. Nucleic Acids Res doi.org/10.1093/nar/gk…

1/n After an arduous but constructive peer review process, we’re excited to share the published version of this work. Lots of added goodies: science.org/doi/10.1126/sc…

So proud of my team for our latest work, led by researcher Mark Katz. Featuring 12 new anti-CRISPRs, ones that clearly evolved from cas genes, and one that is a super broad spectrum inhibitor. Check it out: biorxiv.org/content/10.110…

Second annual phages 5k!!! 100 folks registered for the run! #runningwiththemicrobes #phages2023

They grow up so quick! Congrats to Antonia Roldan for killing her summer project, the first Varble lab alumni! URMC Immunology, Microbiology, & Virology University of Rochester UCF

Great to have Andrew Varble as visiting speaker at Cornell Microbiology Cornell Microbiology. The Peters lab took him out to lunch before sending him back to University of Rochester

Thanks for having me Joseph E. Peters. Cornell Microbiology knows a good time. As they say, Ithaca is George's!

Now Nucleic Acids Res our two back-to-back papers with Giulia Palermo lab! 1) We show that MD-directed point mutations select against #offtargets in #Cas13a, paving the way for new SNP-detecting #RNA-diagnostics. academic.oup.com/nar/article/do… Adrian Molina Souvik Sinha Pablo Arantes - @pabloarantes.bsky.social Amun Patel

Led by Jakob T Rostøl and Nuria Quiles, with Lasa_Lab, we show that prophages utilise noncontiguous operons to balance immunity and autoimmunity. Our results underscore the essential fine regulation of these processes for prophages' life cycle development. nature.com/articles/s4156…

Excited to share my latest work from the @MarraffiniLab, in collaboration with Phoebe Rice, now online nature!! nature.com/articles/s4158… We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria! A thread 🧵: 1/