Great talk at #ASHG24 Ozkar! Check out our corresponding preprint: medrxiv.org/content/10.110…

Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by Xihong Lin #ASHG24 poster 4089F medrxiv.org/content/10.110…

Interested in PRS methods using continuous ancestries information? Check out our recent preprint: biorxiv.org/content/10.110…. The work will also be presented as a ASHG poster at Board 4128T Nov 7th 2:30-4:30 by an excellent PhD student Tony! Feel free to stop by!!

#ASHG24 Interested in how to reliably use AI/ML to accelerate genetic discovery? Stop by poster 4151 this afternoon to chat!

Current polygenic risk scores require binning of ancestry groups but we know ancestry is a continuum. Our study led by Yunfeng Ruan🌻 #StandWithUkraine🌻 introduces DiscoDivas, a new generalizable PRS framework across the ancestry spectrum medrxiv.org/content/10.110… medRxiv PRIMED Consortium

Thank you Pradeep for your support and advice for this project🙏😃 We’re thrilled to introduce DiscoDivas, a new method designed to generate Polygenic Risk Scores (PRS) for diverse espcially admixed populations 1/

Our new PRS paper is out! We introduce a method to create regularized ensemble PRS on GWAS sumstats. Individual-level data is no longer needed for sophisticated ensemble learning Zijie Zhao Stephen Dorn Paper📰:biorxiv.org/content/10.110… Software🧑‍💻:github.com/qlu-lab/PUMAS

Excited to share our latest work in Cell Genomics! Using a novel MR method integrated with AlphaFold3, we identify Alzheimer’s-associated proteins with 3D structural changes. cell.com/cell-genomics/… Andrea Baccarelli Gary W Miller ColumbiaPublicHealth Cell Genomics

Excited to share our new manuscript on evaluating multi-ancestry GWAS methods using large-scale simulations & real data from UK Biobank (N≈324K) & All of Us (N≈207K)! My first thesis paper under the guidance of Pete Kraft & Haoyu Zhang. Available at: medrxiv.org/content/10.110…

Very excited to share our preprint led by Michael Levin Satoshi Koyama Jakob Woerner & with Scott Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! medrxiv.org/content/10.110… medRxiv [1/3]

Delighted to collaborate with J. Hu and Hongyu Zhao to show that genetic mechanisms leading to a high CAD polygenic risk score are heterogeneous, which may have implications for prevention journals.plos.org/ploscompbiol/a… PLOS Comp Biol