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Our latest work asks: How 414 diseases diagnosed early in life impact the lifetime chance to remain childless? Using within-sibs analysis, nationwide data from 🇸🇪 and 🇫🇮 we find large effect of mental health in ♂️ and metabolic disorders in ♀️ nature.com/articles/s4156…

New multinational GWAS on income in preprint. Findings on non-education income’s mental health impact align with our Multivariable MR direct effects analyses x.com/andreu_bernabe…

1/16 Our new preprint is out, in which we developed an approach to transform Polygenic (Risk) Scores (PGSs) to disorder probabilities (i.e. the absolute lifetime disorder risk). Here is a brief overview. x.com/medrxivpreprin…

A beautiful study by Nivard et al. on the direct and indirect genetic effects on school achievement shows that the indirect effects act primarily via dynastic effects rather than genetic nurture. nature.com/articles/s4156…

socioeconomic status, loneliness, and web-based networked masculinities in the risk of mental disorders

Long non-coding RNAs comprise a large part of the genome, yet loss of one copy (haploinsufficiency) of a lncRNA is not known to cause a human disease. Read our preprint to learn how deletions of the lncRNA CHASERR cause a severe neurodevelopmental disorder.medrxiv.org/content/10.110…

Excited to share AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in nature nature.com/articles/s4158…

Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders with Javier González Peñas Álvaro Andreu-Bernabeu CIBERSAM Escéptica IPSMarañón Psiquiatria Infantil and more sciencedirect.com/science/articl…

Finally, we now know exactly which region and cell types in the brain are mediating the actions of GLP1R agonists. As many suspected, it's not the hypothalamus where the magic happens. It's brain stem, particularly a region called dorsal vagal complex (DVC). Two GLP1R

Inarguably the most important human genetics paper of the year, and a landmark moment in the history of neurodevelopmental disorder (NDD) genetics. Mutations in RNU4-2, encoding a small nuclear RNA (snRNA) are among the most frequent genetic causes of NDD, explaining up to 0.4%

I wrote about the knowns and unknowns around polygenic embryo selection, expanding on a previous post about genetic prediction of IQ. A short 🧵:

Congrats to my colleagues at RGC (Sheila Gaynor, Timothy A. Thornton and team) on their new publication in Nature Genetics on value of exome vs genome sequencing in gene discovery. nature.com/articles/s4158… The message is clear: exome sequencing is more cost-effective than genome

x.com/i/article/1842…

I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.110…) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s4158…). A few surprising findings summarized here: 🧵

Este intercambio (junto con los trabajos que citan) entre dos de las grandes figuras de la genética poblacional es un curso avanzado para cualquiera interesado

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity of traits across the severity spectrum. Tweetorial coming soon.

Anatomy of Moncrieff's Anti-Medication Playbook Dr Joanna Moncrieff has a carefully honed 3-step strategy of attacking psychiatry, which she has used with remarkable power against the medical establishment. Step 1: Identify a narrow, technical assertion pertaining to the

The truth is that the scientific process is horribly inefficient and wasteful. But the solution is NOT cutting funds and it’s NOT top down guidance of what should be studied. Instead, we should revolutionize how we publish and improve peer review.

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in Nature Human Behaviour 💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽