Det er virkelig vigtigt, at der hurtigst muligt findes en løsning - så forskerinitierede forsøg igen gøres gebyrfrie. Ellers kan det få alvorlige følger for den frie forskning. Lægeforeningen #sundpol #forskpol Christina Egelund Stinus Lindgreen monika rubin

Gebyrer for kliniske forsøg går ud over den uafhængige forskning. Vigtig artikel i Ugeskrift for Læger ugeskriftet.dk/nyhed/gebyrer-…

Ensuring early robust evaluations of new & emerging healthcare technologies/procedures is essential to provide unbiased estimates of their true likely impact on patient care 1/7
#MethodologyMonday #82

Ny serie i Ugeskrift for Læger om kritisk læsning af syv typer studier:
1. Randomiserede forsøg: ugeskriftet.dk/videnskab/krit…
2. Kohortestudier: ugeskriftet.dk/videnskab/krit…
3. Case-kontrol-studier: ugeskriftet.dk/videnskab/krit…
4. Systematiske oversigter: ugeskriftet.dk/videnskab/krit…

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'Effects of sceptical priors on the performance of adaptive clinical trials with binary outcomes'

onlinelibrary.wiley.com/doi/10.1002/ps…

Another beauty led by Anders Granholm Benjamin Skov Kaas-Hansen INCEPT Anders Perner

For more on adaptive trials in critical care, see atsjournals.org/doi/full/10.11…

In clinical trials, we sometimes undertake #SensitivityAnalysis alongside the main primary analysis. But when should we use them and to what purpose? 1/8
#MethodologyMonday #80

A step into the future of clinical trials, shaped by the critical care community.

PRACTICALPlatform
REMAP Network EdinUni_TRAITS INCEPT PANTHER trial remap-cap Anders Perner Manu Shankar-Hari Ewan Goligher Eddy Fan Danny McAuley Srinivas Murthy, MD, MHSc

🔗 bit.ly/3UYrMjF

HOT of the press
#HOT_COVID_trial on
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in ICU patients with COVID-19 and severe hypoxemia jamanetwork.com/journals/jama/…

We often use patient reported outcome measures ( #PROMs ) in clinical trials, but it can be difficult to choose which to use. There are several elements that are useful to consider 1/8
#MethodologyMonday #78

Love to see an article on this topic.

As someone that’s primarily worked on the “applied” side of clinical trials but with a strong interest in learning and looking for use cases for adaptive trials…

'Effects of duration of follow-up and lag in data collection on the performance of adaptive clinical trials'

Led by Anders Granholm Benjamin Skov Kaas-Hansen INCEPT Anders Perner

Open access: onlinelibrary.wiley.com/doi/10.1002/ps…

Read our team’s second paper of the series that gives an overview of how GRADE is used in clinical practice guidelines led by Anders Granholm Acta Anaesthesiologica Scandinavica

One option for trials running at the same time is #CoEnrollment of patients to more than one study - ie if a patient is eligible for more than one study in their care pathway they have the opportunity to be recruited to both trials. 1/8
#MethodologyMonday #76

Vi søger en #projektkoordinator til INCEPT platformsforsøget
Del gerne og søg, hvis du vil være med til at forbedre behandlingen på ITA og generisk
Rigshospitalet

Sundhedsjobs.dk - Projektkoordinator til INCEPT Intensive Care Platform Trial sundhedsjobs.dk/jobopslag/4600…

If you are a systematic review developers, methodologists, or evidence end-users.

Our paper could be of interest to you. It aims to provide an overview of how GRADE is used in systematic reviews and meta-analyses. onlinelibrary.wiley.com/doi/10.1111/aa…

Haloperidol is by far the best studied antipsychotic in ICU pts with delirium
If clinicians consider using a drug, my suggestion is haloperidol as used in the #AIDICU trial
All RCTs pooled in this SR-MA
ccforum.biomedcentral.com/articles/10.11…

We are increasingly seeing the use of #RoutineHealthcareData in clinical trials-data routinely collected on healthcare systems as part of standard healthcare delivery ie. not specifically collected for research purposes. But when/how should they be used 1/7
#MethodologyMonday #73