Would you give myeloma therapy for MGUS? Probably yes for some cases, after you read this case report in this week's NEJM. The monoclone was linked to anti-PF4 activity with major thrombotic events. Both monoclone and anti-PF4 activity were eliminated post DVd therapy. Remember

Sometimes the significance of MGUS is not undetermined!

Very true Bloodman @AaronGoodman33 most recent is MG of thrombotic significance: See nejm.org/doi/10.1056/NE…

.NEJM recently published a study on #myeloma therapy for monoclonal gammopathy of thrombotic significance. Co-authored by #StanDOM's Giselle Salmasi, the research shows how treating a specific antibody can stop severe #BloodClots. bit.ly/4dBx8HT

More in the NEJM on Monoclonal gammopathy of theombotic significance— Could this be an umbrella term describing different pathophysiologies? vasiliki gkalea Jordan Schaefer Kristi J Smock, MD Vincent Rajkumar Shaji Kumar Angela Dispenzieri Sigurdur Kristinsson Sæmundur Rögnvaldsson, MD, PhD Professor Beverley Hunt OBE (also on BlueSky) nejm.org/doi/full/10.10…

Diagnosis of the newly described thrombophilia, MGTS can be challenging! Read about the issues in our paper in the current issue of the NEJM nejm.org/doi/full/10.10…. Vincent Rajkumar Shaji Kumar Yazan Abou-Ismail, MD - د. يزن أبواسماعيل Professor Beverley Hunt OBE (also on BlueSky) Mayo Clinic Labs Mayo Clinic Pathology

A man with monoclonal gammopathy of undetermined significance and thrombosis was found to have a previously undetected pathogenic monoclonal antibody that activated platelets in a PF4-dependent manner. Read the full correspondence: nej.md/3Zc3pkb

More on the new thrombophilia MGTS from our group. Detection may be complicated!

Mayo Clinic researchers Adam Kanack, Ph.D., Nelson Leung, M.D., and Anand Padmanabhan, M.B.B.S, Ph.D., have identified a novel subtype of a recently identified severe blood clotting disorder called monoclonal gammopathy of thrombotic significance. @nejm bit.ly/419xeTK

The new thrombophilia, MGTS just got more interesting, and complicated! Here is a new paper in NEJM from our group on the challenges of recognizing this disorder: nejm.org/doi/full/10.10… Couple of other recent papers on MGTS: nejm.org/doi/abs/10.105… ashpublications.org/blood/article/…

Use of Mass Spectrometry to Study Antibody Clonality Leads to Identification of Novel Thrombophilia: Monoclonal Gammopathy of Thrombotic Significance [MGTS] [Feb 27, 2025] Murray and Anand Padmanabhan The Hematologist ASH ashpublications.org/thehematologis…

Monoclonal gammopathy of thrombotic / thrombocytopenic significance {MGTS} [Apr 6, 2023] Kanack et al. Anand Padmanabhan @BloodJournal ashpublications.org/blood/article-…

Mass spectrometry is revealing critical insights into monoclonal gammopathy of thrombotic significance (MGTS), offering a new pathway for diagnosis and treatment. This groundbreaking approach could change the way we tackle diseases driven by antibodies. 🔗ow.ly/xw8l50VHqhO

Great article in CAP TODAY MAGAZINE on anti-PF4 disorders!! MGTS (monoclonal gammopathy of thrombotic significance) with its various “flavors”, “HIT-like”, “VITT-like” & “non-HIT/VITT-like”, is going to be an important entity in the thrombophilia field!! captodayonline.com/spectrum-of-an…

Along with collaborators at UT Southwestern Medical Center we report a study in the NEJM on the potential role of monoclonal anti-PF4 abs in recurrent miscarriage. Larger studies to follow! Mayo Clinic Mayo Clinic Labs nejm.org/doi/full/10.10…

Enjoyed this wonderful collaboration between Mayo Clinic Mayo Clinic Pathology and UT Southwestern Medical Center More studies are needed to evaluate this potential link!!

Monoclonal #Anti –Platelet Factor 4 Antibodies in #Recurrent Pregnancy Loss nejm.org/doi/full/10.10…

flora peyvandi We would like to inform you that your post has been published on Hemostasis Today. Thank you for sharing. hemostasistoday.com/science/recurr…

Correspondence: Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss nej.md/4luAlx1 #OBGYN

Mayo Clinic will be organizing this year‘s classical hematology conference in Arizona! If you work in this area or are curious to learn more about topics in this exciting field, join us! The link below provide more information and sign up instructions: lnkd.in/guinU6xj