Interesting series of talks from Amy Williams about Reconstructing Parent DNA and Analyzing Relatives familysearch.org/rootstech/rtc2… #genealogy #geneticgenealogy #RootsTech #RootsTechConnect

Announcing web-based HAPI, a tool that reconstructs data for one parent using data from 3+ siblings and their other parent. Blog post at hapi-dna.org/2021/03/recons…. Paper on this and Ying Qiao's work to reconstruct data for both parents (given other relatives) later this year.

I am hiring! The NIH-funded position is at the postdoc OR postbac level, and the project involves machine learning and genomics. The deadline is flexible even though it says March 19. Contact me directly with any questions. Please RT! haverford.edu/human-resource…

Is there a strong convention for how to represent male X genotypes in VCFs? 1kG has haploid coding. Is that used generally?

The 2021 Great Lakes Annual Meeting of Evolutionary Genomics is next week! We have a fantastic set of student and postdoc presentations, plus keynote speaker @YazBraimah. Registration is free & still open: blogs.rochester.edu/EEB/?page_id=3… We hope you'll join us at #GLAMevogen!

Nice new preprint from Amy Williams et al. To identify relatives based on IBD segments shared between them, one can use the total proportion of the genome in IBD segments (the kinship coefficient). But does it help to also consider the number of segments? 1/7

Just announced: Two open faculty positions in Molecular Biology and Genetics at Cornell! Definitely includes Evolutionary Genomics: academicjobsonline.org/ajo/jobs/19776

Save the date for #ProbGen22: 28th-30th March! Probabilistic Modelling in Genomics is in Oxford, jointly hosted by Big Data Institute, Centre for Human Genetics and Oxford Statistics. Three day hybrid event, US East coast friendly scheduling. More details to follow soon. Please RT!

Our method Bonsai that efficiently infers large and sparse pedigrees is out now in AJHG! embjewett Kimberly M Adam Auton

Just posted a tool that plots numbers of IBD segments relatives share for varying length thresholds (0 to 20 cM) hapi-dna.org/ibd-sharing-ra… Long segments do show up in rare 7th and 8th cousins, though not sharing segments of any length does not rule out those relationships.

A cool new preprint by Amy Williams and @SiddharthAvadh1. They developed a method to infer the ancestry of the parents of a target individual (without the parents!), plus the admixture time in the history of each parent. How does that miracle work? biorxiv.org/content/10.110…

We are looking for a strong computational intern this summer to analyze runs of homozygosity in millions of individuals. Please get in touch if you are interested! 23andme.com/careers/jobs/5…

New tool for genetic genealogists! DRUID estimates the a parent's shared cMs to a relative using segments from two+ siblings. Tool: hapi-dna.org/druid/ Blog post: hapi-dna.org/2022/02/druid/

I've released a new tool today at dnapainter.com/tools/sci with an explanatory blog post at dnapainter.com/blog/put-your-… Amy Williams has a blog post with technical background and her version of the tool. I hope this is useful!

It was a pleasure to work with and learn from Jedidiah Carlson @HennLab dana r al-hindi and nature in the processing of writing this commentary: nature.com/articles/d4158…. Thanks especially to Jedidiah Carlson for suggesting a lead photo centering the victims of hate crimes by white nationalists. 1/3

Had a lot of fun presenting this work at #BoG24! Look for applications coming soon - first up is phasing (in collaboration with 23andMe Research and Amy Williams)

23andMe Research Amy Williams And our preprint is live! A great collab w Amy Williams and 23andMe Research, led by my amazing grad student Cole Williams ! “Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin classification of variants.” bioRxiv doi: biorxiv.org/content/10.110…

Fun work led by Ying Qiao to reconstruct parents’ DNA using siblings and their relatives. The new method HAPI-RECAP has error rates on par with direct genotyping. Given big enough families can nearly reconstruct the full genomes! 23andMe Research collab biorxiv.org/content/10.110…

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