Really nice work from Emily Martin and Jon Wall development evuzamitide SPECT tracer for pan-amyloid imaging
#ACC24
#amyloidosis #cardiotwitter

A real vibe shift is afoot in tech and business culture.

Masterful overview of landscape of therapies for TTR #amyloidosis
2nd annual #BZNamyloid conference Houston Methodist

#cmr2024 is next week

We will share the first ever look of the effect of #aficamten on cardiac structure and function

#CardioTwitter #HCM

DepleTTR-CM trial is now on clinicaltrials.gov
Phase III trial of ALXN2220 (NI006) vs placebo
Fibril remover ( phase I results nejm.org/doi/full/10.10… )
1000 patients, ATTR-CM, loop diuretics, NTproBNP > 2000.
PEP: ACM+CV events

classic.clinicaltrials.gov/ct2/show/NCT06…
#CardioTwitter

With a 13% positive rate in healthy individuals!

If there is 13% early cancer rate in a general population, that should be the real headline.

That’s 650, give or take 1, people that they most certainly did not help and likelyincreased their anxiety and lead to unnecessary…

Venk Murthy MD PhD I interpret MRI on a regular basis and MRI is not a good screening tool without a high pretest probability and even then iffy at best. By the time we can see it on imaging (except maybe mammography) there is likely to be morbidity associated with treatment.

#amyloid is everywhere, incl.bladder, and prostate and not all 'localized' as previously thought. ATTR amyloidosis was seen in over 1/3, often was the first manifestation, ~ 80% subsequently found to have ❤️involvement. sciencedirect.com/science/articl…

124I-evuzamitide PET/CT accurately identifies cardiac light chain & TTR #amyloidosis , excludes amyloid in healthy controls, & may be better than 18F-florbetapir for TTR quantification. bit.ly/46bb7LN

#ThinkPET #cvPET #JACCIMG Shilpa Vijayakumar Sharmila Dorbala

The ATTR-ACT trial showed that tafamidis was superior at preventing major adverse events and functional decline in amyloidosis. bit.ly/40QXOyX #HeartFailure

Low Sensitivity of Bone Scintigraphy in Detecting Phe64Leu Mutation-Related Transthyretin Cardiac Amyloidosis | JACC: Cardiovascular Imaging jacc.org/doi/abs/10.101…
A negative bone scintigraphy does not rule out an amyloid cardiomyopathy ! Dra. Isabel Carvajal. AMILO-LATAM Alex Felix

Cardiac Amyloid Detection by PET/CT Imaging of Iodine (124I) Evuzamitide in systemic #amyloidosis sciencedirect.com/science/articl…

Have you heard of iodine (124I) evuzamitide (124I-P5+14)? Two papers show that this might be the next big thing for the imaging of cardiac amyloidosis.

Molecular Imaging of Systemic and Cardiac Amyloidosis jnm.snmjournals.org/content/64/Sup… Amyloid PET imaging is expected to play a crucial role in early diagnosis and in monitoring of therapy Sharmila Dorbala SNMMI European Society of Cardiology Journals Alex Felix Dra. Isabel Carvajal. Sergio Kaiser MD, PhD, FACC, FESC 🇧🇷🇮🇱🇷🇴🇺🇦 Christiane Wiefels Rob Beanlands

Wonderful review of PET tracers in #amyloidosis by Dr Dorbala Sharmila Dorbala Molecular Imaging of Systemic and Cardiac Amyloidosis: Recent Advances and Focus on the Future jnm.snmjournals.org/content/64/Sup…

This is my patient and his story is heartbreaking. Thank you Circulation Quality and Outcomes for amplifying his voice. We can do better for him.

*Posted with patient’s permission (and at his request) ahajournals.org/doi/10.1161/CI…

Good news for all of us. Congrats to the team. This new TTR silencing approach using CRISPR is coming soon as part of a phase III trial
#amyloidosis #CardioTwitter

Is it time for PET in cardiac amyloidosis? Indeed, explains the luminary Sharmila Dorbala Brigham and Women’s Cardiovascular Imaging Program Harvard Medical School at #ASNC2023 ASNC Society with key points - PET is:
1) highly quantitative & sensitive
2) images the heart & whole body
3) detects all forms of amyloid
#ThinkPET #CVNuc

Congrats Dia Smiley for the #ASNC2023 award in #Amyloidosis studying the new tracer 124I-Evuzamitide. Great potential for a more sensitive tracer than PYP! ASNC Society Bruno Lima Ggrossman Parthiban Arumugam Ana Michel Alex Felix AMYLOIDOSIS ALLIANCE Amyloidosis Research Consortium #ThinkPET

Pfizer Inc. ASNC Society Advances in the Non-Invasive Diagnosis of ATTR-CM #Amyloidosis Pfizer Inc. ASNC Society
📌SPECT findings