Elastic fibers pattern in benign nevi vs melanoma #SilviPearls #dermpath: 💠 elastic fibers intermixed bw nests & individual melanocytes in banal nevi 💠 melanoma has lost/nearly lost elastic fibers & pushes the UV altered elastic fibers downwards 💠 elastin stain useful

Adult. Biopsy of supraclavicular fossa lymph node. Chromogranin A and synaptophysin both positive. No known primary tumour. How would report this? Poll in next tweet. Would the Ki67 influence what you call it? #pathology

Biopsies of a nasal cavity mass from 40 year old. Unusual case that was eventually diagnosed on the resection specimen. Not my area of expertise, but was sent as possible lymphoma. Differentials and how would you approach this? #pathology #ENTpath

In the comment you will see the surprise. #dermpath #pathology

A very nice summary of peripheral T cell lymphoma classification by Dr. Barbara Pro at #HOPLive24 Sadly our treatment options remain very limited compared to our understanding of the disease biology. My takeaway: need better biologically-informed clinical trial design!

Cool case! #diagnosis? Yale Dermatology GR had a case of this today! both arms affected, photodistributed; #dermpath "red-orange, regularly spherical, of overall smaller dimension, and negative for Perls iron stain" jaadcasereports.org/article/S2352-… JAAD Journals #dermatology #pathology

Finger of 20yo M, diagnosis? A) Plexiform neurofibroma B) Cellular neurothekeoma C) Dermal nerve sheath myxoma D) Myxfibrosarcoma #DermPath #BSTPath #Pathology #PathTwitter

Follicular lymphoma with BCL2 rearrangement by FISH & unusual overexpression of CCND1 by IHC (CD5 & SOX11 negative; CCND1 rearrangement negative by FISH). This rare finding has been reported previously➡️shorturl.at/lzDOU but is worth to be aware of #hemepath #lymsm #PathX

p53 in vulvar dysplasia: • A basal sparing pattern supports HSIL (uVIN/HPV-related VIN) • Basal keratinocytes are negative • Remainder of the epithelium shows a wild-type (mosaic) pattern • This pattern is as suggestive of HSIL as a block positive p16 #pathology #pathtwitter

p53 pattern in dVIN = A, B, or C? #GynPath #PathTwitter #Pathology #DermPath

VAAD/deVIL: basal/scattered wild-type p53 patterns no atypia, anl maturation, hypogranulosis, flat + cytoplasm pallor (VAAD) or exophytic (deVIL) dVIN: mutant p53 (e.g., homogenous basal & midepithelial) basal atypia, anl maturation, hyperchromasia, nucleoli 📽️HPV-independent

20 F arm nodule. Diagnosis? If you could only do ONE STAIN, what would you do? Digital slide🔬 kikoxp.com/posts/17751 Answer ✅ youtu.be/obIibd_Xzlc?si… #pathology #pathologists #pathTwitter #BSTpath #dermpath #dermatology #dermatologia #dermtwitter

Pathologists! Check out this fibrin associated large B cell lymphoma in an atrial myxoma. Typical features: incidental finding, large pleomorphic EBV+ B cells with non-GCB phenotype, often CD30+, in a background of debris, typically cured by excision. #lymphoma #hemepath

How to manage your emotions

CD45+, CD43+, so could be ALCL, but CD30 was negative. Note the fine chromatin of the neoplastic cells, suggesting blasts. Additional IHC: CD68+, lysosome+, NPM1+. Dx is myeloid sarcoma, NPM1+, c/w NPM1 mutation. #hemepath #heme #myeloid

Happy to conclude the annual #ASCP2024 meeting by presenting our topic on aggressive cutaneous lymphoma with my wonderful colleague UVA Pathology Dr Linglei Ma.

Aggressive angiomyxoma: - "Aggressively thick-walled" blood vessels - Small, bland spindle cells in a myxoid background - Extravasated red blood cells common WSI and more info: pathlibrary.com/slidebox/?case…

When lymphoid follicles start looking like continents or animal crackers, think HIV (florid follicular hyperplasia)!

Close up of the base of the nevoid melanoma case posted today. Showing the useful parallel theque pattern described by Elston. PMID 26299955

NUT Carcinoma. 4 cm axillary mass in a 60-year-old man. Small round blue cells with abrupt squamous differentiation. BRD4-NUT fusion detected via FISH.