Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth dlvr.it/TG4KSC

News coverage from Karolinska Institutet on our latest paper: Very happy with what we have achieved so far with Morteza Mahmoudi, PhD lab. news.ki.se/new-method-for…

Thrilled to share our approach for language model-guided discovery of unknown mammalian metabolites: DeepMet. We’ve now used this approach to discover ~50 new human and mouse metabolites! biorxiv.org/content/10.110…

I’m excited to share our latest study in @nature on this novel compound called Gliocidin, that targets glioblastoma (#GBM), the most malignant brain tumor. #drugdiscovery #cancer #cancermetabolism GSK Graduate School Memorial Sloan Kettering Cancer Center nature.com/articles/s4158…

In this work led by Zhaowei Meng , we present the one-pot time-induced (OPTI)-PISA assay, for automated target identification across the entire proteome. OPTI-PISA significantly reduces sample requirements to sub-microgram levels, suitable for NanoProteomics. pubs.acs.org/doi/10.1021/ac…

Postdoc position in our lab, focusing on the role of oncometabolites in liver cancer using a variety of cell biology, biochemistry and proteomics techniques. Freshly funded by the prestigious Cancerfonden Please apply or share. ki.varbi.com/en/what:job/jo…

1/ Over a century ago, scientists uncovered a curious link between the gut & the pancreas. This sparked decades of research, culminating in one of the greatest medical breakthroughs. This is the story of GLP-1 that I would like to share. 🧵

The critical role of the protein corona in enhancing the depth and precision of protein quantification in plasma proteomics: …iencejournals.onlinelibrary.wiley.com/doi/10.1002/pm… MahmoudiLab Saei Lab

Amazing work, the type of which will accelerate drug discovery: nature.com/articles/s4158…

Invited to the Cancer Research Horizons and Oncode Institute to Hepatocellular Carcinoma Think Tank in London. Identifying and progressing novel therapeutic approaches in liver cancer! Hope to connect with great scientists in the area!

Looking at bioinformaticians’ profiles these days, you'd think everyone has decades of experience in cutting-edge single-cell and AI-driven bioinformatics. But something’s missing… 👇

🚀 We're looking for a postdoc to join an exciting project between the Chronobiology Lab (Paul Petrus) and Saei Lab at Karolinska Institutet! We're looking for someone with skills in endocrinology, proteomics and bioinformatics. Apply by May 8. ki.varbi.com/en/what:job/jo…

Congrats to Daniel Dan where he shows in human ART1, binding of NAD+ and l-arginine-like substrates happen through a random mechanism. Followed by chemistry in a ternary complex, and ordered release of the products #enzymes #kinetics #NAD #ADPribosylation #PARP👇

Honored to be one of the four awardees of the Novo Nordisk Excellence Emerging Investigator Grant - Endocrinology and Metabolism 2025. I am incredibly grateful to the review committee for recognizing the potential impact of our research and to the Novo Nordisk Foundation Foundation for

Scientists just cracked the multiple sclerosis code after decades of searching. Two specific gut bacteria are triggering the disease, and they've proven it using identical twins and mice. This changes everything we know about MS:

In a new Science study, researchers report a powerful tool to design small, folded protein domains that interact tightly with intrinsically disordered protein regions. The authors suggest potential applications in cellular imaging, in vitro peptide capture, and modulating cell

Our PerturbNet paper is the cover article for Molecular Systems Biology! The image depicts our genAI model that predicts how cellular perturbations—including chemicals, gene knockdown or overexpression, and protein mutation—shift single-cell gene expression. 🧵