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The clustering algorithm FLSHclust identifies previously unknown CRISPR-linked systems using a mining approach with great potential for advancing biotechnology development in both research and the clinic. #NBThighlight science.org/doi/10.1126/sc…

Check out our latest work on a new algorithm for protein clustering and the discovery of new CRISPR systems! More on this soon. So grateful to have this work published by Science Magazine !

CRISPR defense now known to target mRNAs in ribosomes - the source of all proteins in the cell - in order to prevent viruses from making proteins. Truly amazing! science.org/doi/10.1126/sc…

What's neat is that, using a bioinformatics approach, Han Han Altae-Tran et al. recently found putative examples of even more TnpB domestication events, including associations with transcriptional activators! Maybe we'll need a new name for those 😁 doi.org/10.1073/pnas.2…

A new preprint from Sam Sternberg Sternberg Lab shows that TnpB, the ancestor of CRISPR-Cas12, has been naturally co-opted for RNA-guided transcriptional regulation of bacterial flagellin systems! doi.org/10.1101/2023.1…