Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM biorxiv.org/cgi/content/sh… #bioRxiv

Cryo-EM reveals the regulation of RUVBL1 and RUVBL2 AAA-ATPases by DHX34, a helicase involved in NMD is now out bioRxiv Llorca lab CNIO Stop Cancer . In collaboration with @nelehug Javier F Caceres MRC_HGU. bioRxiv 2020; doi: doi.org/10.1101/2020.0…

Very happy about our collaboration with Oscar Llorca, Andres Lopez-Perrote and colleagues at CNIO

Have a look at our latest review on the RUVBL1–RUVBL2 complexes. Great work by Maria I Dauden, and Andrés López Perrote Oscar Llorca done at CNIO Stop Cancer. sciencedirect.com/science/articl…

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Just out! RUVBL1/2 strikes back, this time together with ZNHIT2, a complex involved in the maturation of PRPF8. The great Marina Serna, Ana Corpalez Gonzas, Sofía Cabezudo and Andrés López Perrote spearheading this project. Full text link below 👇

Great Tec4Bio meeting with all our members and finally in person!🎉 F. Moreno-Herrero J. Alegre-Cebollada Miguel Angel delPozo Oscar Llorca Ricardo Garcia @icmmcsic and Gustavo Plaza Universidad Politécnica de Madrid Thanks to Xavier Trepat and David Rueda for taking part in it. Looking forward the next one.

📸Hoy hemos mantenido una reunión de seguimiento del consorcio que coordina nuestra investigadora Maite Huarte, en el que participan CNIO Stop Cancer y Centro Nacional de Biotecnología (CSIC) 🔝Proyecto que busca nuevos tratamientos para el cáncer colorrectal financiado por #CaixaResearchFundlaCaixa

Great meeting Cima Universidad de Navarra together with Llorca lab and Maite Huarte in the context of our CaixaResearch project! Thank you Maite for hosting us!!

Thanks to #CNIOStopCancer colleagues for these two days of retreat full of ideas and inspiring talks. Shared time makes stronger teams!! 😃

PAPER ALERT🔥 We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With Marina Serna and Cláudia De Brito leading the way. Proud of our collab with the @surrey_lab at the Centre for Genomic Regulation (CRG) ! science.org/doi/10.1126/sc…

Big congratulations to our new #CNIOStopCancer PhD Dr. Natalia Cuervo Iturrioz! 🎉 👉#CNIOPhDThesis: 'Human WAC is a partner of chaperone complexes involved in the assembly and activation of mTORC1'. Exciting times are ahead! 👏 🎓Directors: Oscar Llorca and Marina Serna.

And also... 🔥pre-print alert🔥 We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone. A study led by Andrés López Perrote (CNIO Stop Cancer) and Alberto Palacios (from david alabadí 🍊 dalabadi.bsky.social's lab at IBMCP - Instituto de Biología Molecular y Celular). Check it out 👇 biorxiv.org/content/10.110…

Thrilled to share our last work Cell Reports Physical Science Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥 All-Llorca lab work led by Carmen Garcia and Andrés López Perrote Link below 👇 doi.org/10.1016/j.xcrp…

And a movie with those beautiful high-res densities 🤓

The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by Marina Serna and Fabian Zimmermann and a fun collab with Jens Luders @LudersLab.bsky.social IRB Barcelona. authors.elsevier.com/c/1jpyq_Yv6zvB…

Online now! The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP dlvr.it/TJC8Zg

Hi, we have published a study in Structure that you may like it! This work is the result of a fantastic collaboration between our group IBMCP - Instituto de Biología Molecular y Celular and Llorca lab (CNIO Stop Cancer), aimed at understanding the role of the HSP90 cochaperone R2T in plants doi.org/10.1016/j.str.… 👇

Our take on the struture of the R2T complex 🌱 Now out in Structure! A fun collab led by Andrés López Perrote and the david alabadí 🍊 dalabadi.bsky.social lab at IBMCP - Instituto de Biología Molecular y Celular . Check it out in the next post 👇

Link to the paper: cell.com/structure/full…