Are AI models actually ready to upend drug R&D today? New results from one contest suggest maybe not. About 2,00 teams competed and struggled to predict if molecules bind to certain proteins. My latest talking to Leash Bio CEO Ian Quigley: endpts.com/in-a-reality-c…

Taking a moment to clone the citrate/succinate antiporter into my protein expression vector so we can test if we can select E. coli using citrate in aerobic contions. The lemon in my lemonade cloning. Come clone with me! Thread 1/n #FlowersForEveryone

Our Kaggle competition to predict small molecule binding is over, and nobody was able to generalize into novel chemical space whatsoever. There's a lot of work to do! Blog post: lnkd.in/gW7VNaEa Endpoints: lnkd.in/gUefHgJg

These competitions are SUPER important for our industry 🧬 If you're interested in this, ALSO check out: > The Align Foundation's competition > biomlsociety's competition > Kaggle competition by Leash labs (Ian Quigley)

Our Kaggle competition got a nice writeup by Derek Lowe. It's true, predicting novel chemical material is hard! science.org/content/blog-p…

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/

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Issue 16 is complete! On the cover: a superimposition of three stages of embryonic mouse lungs (E12 in white, E13 in cyan and E14 in magenta) demonstrating changes that can be observed over a 3-day period. See Research article by Paramore et al. journals.biologists.com/dev/article/15…

Toshirô Mifune and Akira Kurosawa during production of RED BEARD (1965)

Preprint just dropped!🎙️We discover molecular mechanisms of the excruciatingly painful sting of the Scarlet Velvet Ant (Dasymutilla occidentalis). Title: "Multiple mechanisms of action of an extremely painful venom." 🧵 1/N biorxiv.org/content/10.110…

I have designed and used degenerate primers to clone genes.

Nematode worms FTW!

PI3K dependent rearrangement of the actin cytoskeleton following the addition of Class I PAK kinase-inhibitor. Please read about it in our pre-print!

It's #MicroscopyMonday !🔬 This Fluorescent image of an Acropora sp. showing individual polyps with symbiotic zooxanthellae placed 15th in the 2023 Nikon Small World competition. (5x Mag) Credit: Dr. Pichaya Lertvilai, UC San Diego, Scripps Institution of Oceanography

BELKA, a massive public molecule-protein interaction dataset created by Leash Bio, is now available on Polaris! Access it with just a few lines of code: polarishub.io/datasets/leash… BELKA contains 100M molecules screened against 3 protein targets. If you didn’t get to participate in

zarr_dev And a big shout-out to Leash Bio Ian Quigley andrew blevins for their trust and patience! With 100M+ rows and 120GB+, their awesome BELKA dataset was the perfect resource to test our assumptions and implementation. Check it out on Polaris: polarishub.io/datasets/leash…

Hey Alta Ski Area you guys are the best for allowing uphill traffic

Lastly, and this is definitely the icing on the cake -- we found a gene regulatory mechanism that can likely explain all of this. Mutants for this mechanism show *zero* epigenetic aging, as well as no increase in TE transcripts in older tissues