Synbio loves IFFLs, including recent cool works from ElowitzLab and Katie Galloway. We implemented protease-based IFFLs with unique features for dosage control, and demonstrated them against Rai1 that underlies conditions like SMS and PTLS doi.org/10.1101/2024.1…

embopress.org/doi/full/10.10… AdamArkin_Lab Part 1 of 2 of postdoc work. High-throughput protein identification method with lots of potential. protocols.io, FigShare, and Github available. Addgene plasmids will be release soon! Hope it is helpful to folks!

We're recruiting a technician to help with our work on neurons! 🧠 Great opportunity to work with Di Wu and other awesome scientists Caltech. Please RT.

Happy to have contributed to this awesome project spearheaded by two talented grad students Carlos Aldrete and Connor

So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…

What controls the viability of encapsulated cells in injectable hydrogels? Out today in Biomaterials Science, our new paper uses rheological tools to show that yielding speed affects viability independently of stiffness! Tweetorial below: pubs.rsc.org/en/content/art…

LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.

🎉 Congratulations to Xiaojing Gao, winner of the 2025 BioInnovation Institute & Science Prize for Innovation for his work developing an innovative programmable RNA sensor and molecular tools to improve mRNA vector therapeutics. Learn more: scim.ag/4hYXSDI

Very few instances I read a paper and go wow, but this one takes the cake. Congrats to ElowitzLab on this elegant work.

Excited to share our latest collaboration with Quan Yuan's lab at NIH: pnas.org/doi/10.1073/pn…

The machine-guided humanization paper is out after peer review! doi.org/10.1016/j.cels… Key contributions from current and previous international students on visas, representing 5+ countries.

🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…

We're hiring Kemijski inštitut ! We aim to translate technologies of synthetic biology toward therapeutic applications, using both protein and RNA-based strategies. PhDs or MSc excited about #syntheticbiology #biotech #proteindesign #RNAdesign are invited to inquire and apply. Pls RT🔁

Have you always wanted to take a protein from its native context and make it work elsewhere? Our novel sampler computationally “cytosolize” a secreted enzyme while maintaining its structure, generalizable to other multi-objective guided generation tasks biorxiv.org/content/10.110…

I am thrilled to announce that I am launching my lab at the Salk Institute in September! The Blum lab will study the physiological effects of plant-derived molecules, with a particular focus on the mammalian immune system.

If I was looking for a faculty mentor I would rush to Jamie!

The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science. Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving  4–22% success rates with efficient experimental

My postdoc work is now on bioRxiv! We combined engineered bacteria with hydrogels to create implantable living materials. These living materials safely confine microbes while enabling them to sense disease and release drugs on demand. 🔗 biorxiv.org/content/10.110…