Mouse studies often fail to replicate in surprising ways. Let me enumerate some of the ways: 1. Mice handled by male scientists feel less pain. The finding holds true when a female scientist does the experiment but holds a t-shirt, previously worn by a man, near the mouse. The

Most engineering limits are set by materials, and most material limits are set by the density of atomic defects. Ergo, what keeps us from building an elevator to the stars is mischievous atoms misbehaving. Same thing applies to white couches in a house with kids.

Interesting: “The great change brought by humanity is that we wound up accumulating tech faster than we lost it.” — from The Scaling Era Has anyone defined a dimensionless number for this? If not, could we call it the Shannon Number (after the Shannon Ratio)? Shannon < 1 = fall

Nabla is on 🔥!

Too many techbio companies focus too early on their own assets, making it hard to truly invest in the platform that makes them special. Nabla shows a better way -- start with revenue generating partnerships, then vertically integrate over time.

Intuit has got to be one of the craziest customer discovery stories. They followed people home after they purchased Intuit's personal accounting software and realized that people were buying the accounting software for their small businesses. And thus QuickBooks, ~$10B/yr.

Finding a niche often drives up value & pricing. Real example: Infant's Tylenol is ~4x the price per mg of drug vs. Children's Tylenol. A tired, stressed parent walking into the pharmacy will buy at a high price to soothe a crying baby.

did the flippening just happen?!?!?

Love Steve Ballmer's "patient, long-term, hardcore" approach to building on his Acquired podcast episode.

Today marks the two year anniversary of Yasir and I joining forces to found Aalo. Incredibly proud of what we’ve built together. Just the beginning! Yasir Arafat Aalo Atomics

The erosion of American norms around private ownership of companies is surprising and very bad. Seems like a straightforward conservative position to not let the federal government control private enterprise.

Wild how much Aalo has accomplished in just 2 years!

The level of intensity at TSMC is pretty crazy. My brother in law (who has a PhD) was expected to work 6 days a week. Monday to Friday was usually 9am till 12am if nothing went wrong. Many days it was as late as 2am. He also worked at least Saturday or Sunday, if not both.

Daisyworld blew my mind when I first simulated it! The concept that life could make the world to be habitable for life was wild.

Very excited that the clinical trial results for our PRIMA retinal prosthesis are published today in the New England Journal of Medicine! This is the first time that patients who are blind due to photoreceptor loss have been able to intuitively see again.

What ppl think we're saying: “We’re the first to build nuclear hardware in a factory.” This is of course not true. What we're actually saying: “We’re the first to build a fully vertically integrated factory that outputs nuclear power plants. Raw materials in, completed

This, for everything

Jensen doing the hard work of customer discovery more than decade in as the CEO!

When I was 12 there was a propane gas leak in my house and a spark caused an explosion. My single mother was in the house, suffered brain damage, and became permanently disabled after that. We relied on food stamps to get by for a bit. I've gone on to have a great career and now

Is it possible to get financing against things like milestone payments in co-development partnerships? Seems like that'd be a killer product for a techbio startup.