New paper alert! What controls where and how a cell builds a kinetochore? Turns out you don’t complex regulation or even DNA. Simply bringing together a single protein at a high local concentration is sufficient to trigger robust kinetochore formation. biorxiv.org/content/10.110…

Kinetochore community save the date! The 8th EMBO Dynamic Kinetochore Workshop will happen from 17–20 June 2024 at Caux in Switzerland. Sign up for notifications at coming-soon.embo.org/w24-37 - the full website will be launched in September. #EMBOkinetochore2024 #DKW2024

On Thursday, I’m giving an NHGRI intramural seminar: Genetic conflicts during meiosis shape the rapid evolution of essential chromatin proteins; work of Ching-Ho Chang Aida de la Cruz, & Emily Coelho among others genome.gov/event-calendar…

Can we amplify RNA without reverse transcription to cDNA? Based on the finding that ssRNA template can be directly amplified by T7 in vitro transcription, we invented LAST-seq for RT-free single-cell RNA sequencing, offering a high capture efficiency. genomebiology.biomedcentral.com/articles/10.11…

Congratulations to Tom Misteli of the National Cancer Institute on winning ASCB’s 2023 E.B. Wilson Medal--presented at #cellbio2023 to distinguished researchers for their far-reaching contributions to cell biology over a lifetime in science. @NCITomMisteli National Cancer Institute

Our first research paper is now published at nature! 🎉🐭🔬We found that F1 hybrid female mice can have defective chromosome condensation in oocytes, creating a reproductive isolating barrier. Congrats again to our postdoc, Warif El Yakoubi🎊 nature.com/articles/s4158…

Congratulations Joana and team!

Huge thanks to Chienlab @UMassBMB and UMass Molecular & Cellular Bio for hosting me at the MCB seminar series yesterday! UMass Amherst has a great community and wonderful trainees, I really enjoyed all of my discussions!

Now recruiting: enthusiastic postdocs to use advanced imaging methods to dissect biological processes. My group at Harvard has 2 Wellcome-funded positions examining the underlying mechanisms and resultant forces driving bacterial growth, division, and antimicrobial resistance.

📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly bit.ly/4b8wpNA

Our department is looking for a computational biologist. Please help spread the word!

My department is hiring! Tenure track faculty position in genetics. Researchers using any eukaryotic model, including fungi and plants are encouraged to apply! We are a broad biology department with strengths across all kingdoms. Join us! Apply by March 1 tinyurl.com/y4evds8p

Preprint🚨on a new mechanism of genetic cheating in meiosis! 🧬We found that a mouse selfish DNA, R2d2, combines the elements of both male and female meiotic drivers! (gamete sabotaging in female meiosis) biorxiv.org/content/10.110…

Comprehensive cancer survivor care is essential. Learn more about the latest here:

We're deeply saddened by the passing of Dr. Maxine Singer, esteemed scientist emeritus at NCI’s Laboratory of Biochemistry and Molecular Biology. Her groundbreaking work and dedication to science have left an enduring legacy. Our thoughts are with her family and colleagues🌹

📢ACCESS DENIED!! Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited? Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to

Happy to share our work about DNA supercoiling, an understudied physical feature of the double helix and the chromatin. 1/5 nature.com/articles/s4159…

🎉 Exciting Announcement! 🎉 “Histone Modifications and Chromatin Structure Symposium” 🗓️ Dates: October 17-18, 2024 📍 Location: National Institutes of Health, Bethesda, Maryland The NCI Center of Excellence in Chromosome Biology is delighted to invite you to our upcoming

Hurry! The deadline to register for the exciting symposium on "Histone Modifications and Chromosome Structures" is quickly approaching—this Friday, October 4, 2024. This symposium featuring talks by 25 renowned scientists is free to attend. To secure your spot, please visit:

It was wonderful to be part of the group honoring the memory and contributions of David Allis and Gary Felsenfeld to the field of chromatin biology and epigenetics at the National Cancer Institute. National Cancer Institute Thanks to Shiv Grewal Shiv Grewal, and the organizing committee at NCI for