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Sad to report more upsetting news…actor Tony Sirico has died at 79. He is most known for his role as Paulie in the Sopranos. Before acting he was connected to the Colombo Crime Family and changed his life after a prison stint and got into acting. RIP legend

Happy like a new year to see the first work of my postdoc out in Cell! Here, we explore the anti-phage potential of accessory genes carried by phage satellites (PICIs), i.e. genetic elements mobilised by phages 🦠🧫 bit.ly/3K1XQeM Summary🧵

The lab celebrated some big milestones this week with a few well-earned picklebacks.

Absolutely JAZZED to start 2023 opening the Jordan lab @UW_Microbiology! A dream come true that wouldn't have been possible without the generosity and support of Benjamin tenOever. Can't wait to see what this adventure has in store! 😁🫠😬🙃

If this pic doesn't entice you to join the Varble lab, you should check out the awesome science he's doing!

Pleased to present the final version of work showing how RM systems resolve the type VI CRISPR immune response. We’re very proud of Maddie and Lexi’s efforts and hope it spurs more investigations of defense systems working in concert with each other

Postdoctoral position available!!! Gram-negative bacterial infectious disease pathogenesis and innate immune responses. [email protected]

The lab celebrated the bittersweet departure of Maddie Williams and Mark Katz for their graduate studies by partaking of Washington’s finest vintages on a sunny evening

So proud of my team for our latest work, led by researcher Mark Katz. Featuring 12 new anti-CRISPRs, ones that clearly evolved from cas genes, and one that is a super broad spectrum inhibitor. Check it out: biorxiv.org/content/10.110…

Raising Canes files plans for first Seattle-area location bit.ly/3OMFzGr

News on the Zorya defense system: anchors to the peptidoglycan and detects membrane disruption by phage. It has a flagella-motor-like device that rotates once activated. So cool! I've been waiting for insights on Zorya since we first described it 5 years ago. Congrats Tylor&co!

We wrote a Preview on the excellent recent paper from the Vasili Hauryliuk Gemma C Atkinson groups, check it out! authors.elsevier.com/c/1jPEg6t8JEqo… cell.com/cell-host-micr…

Anyone else been waiting for ONIX2 plates from MilliporeSigma? We've been waiting for 4 months for plates to ship, with no end in sight! What gives?

The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team! nature.com/articles/s4158…

We are hosting the NW ASM Branch Meeting here in Seattle November 9-10! Microbiologists of the Northwest, please register and submit your abstracts at nwasm.org

Many bacteria have >1 CRISPR system, and they affect each other! Shally Margolis found a 3-way interaction that leads to primed adaptation in the RNA-targeting type VI system, check it out:

Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 science.org/doi/10.1126/sc…

1/ Today we announced new research in the ability of AI models to precisely modulate protein-DNA interactions without iterative lab screening. 🧵

Excited to share our last collab paper, now out in print Science Magazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 science.org/doi/10.1126/sc…