We used the power of explainable AI 🧠+🤖 to identify a crucial biomarker that reflects the recovery process in DBS patients with treatment-resistant depression. Read the full paper here: nature.com/articles/s4158…

New paper! A universal pattern of brain wave frequencies. They are slower in deep cortical layers and faster in superficial layers. When something is this ubiquitous, you know it is doing something important. picower.mit.edu/news/study-rev… Work by Diego Mendoza-Halliday Alex James Major

New paper "A ubiquitous spectrolaminar motif of local field potential power across the primate cortex" published today at Nature Neuroscience! nature.com/articles/s4159… A collaborative effort with Earl K. Miller, Diego Mendoza-Halliday, Alex James Major, Robert Desimone, and others 1/n

A motif of local field potentials that maps onto the anatomical cortical layers across cortical areas, and may represent a ubiquitous layer- and frequency-based mechanism Diego Mendoza-Halliday Alex James Major Robert DeSimone Earl K. Miller André M. Bastos nature.com/articles/s4159…

Preprint 🚨Spearheaded by @rm_koehler and co-lead by John-Dylan Haynes. We trained invasive brain signal decoders to elucidate shared therapeutic effects of #dopamine and deep brain stimulation for self-initiated actions in #Parkinson's disease. doi.org/10.1101/2023.1… 1/n🧵

As one might expect if one thinks beta has a role in top-down control (as I do). Cortical beta oscillations map to shared brain networks modulated by dopamine doi.org/10.1101/2024.0… #neuroscience

Intrigued to discover more about how DBS reveals & therapeutically impacts on the dysfunctional circuits behind different brain disorders, from OCD to dystonia? 🪄🧠 So were we! Join us on this deep dive from core to cortex – now out Nature Neuroscience: nature.com/articles/s4159… A 🧵

New paper from Chand lab! We use multimodal graph combination to identify cell types in several areas of mouse ctx from ephys alone. Verified via optotagging. Building towards a future with cell types in every recording. Tweeprint when im not at Cosyne! biorxiv.org/content/10.110…

Tweeprint for those interested! We developed a method, PhysMAP, to identify cell types directly from electrophysiology and show that it interpretably reveals excitatory and inhibitory cell types (PV+ and SST+) of different layers in mouse cortex. 1/8 biorxiv.org/content/10.110…

My first last author paper just got accepted.😍 Thanks to the team, Dr. Matthias Gmeiner and Prof. Gruber!

Our new results reveal the likely cellular/anatomical substrate for the spectrolaminar motif: biorxiv.org/cgi/content/sh… 2/6

Yeah, we did. scientificamerican.com/article/scient… #neuroscience MIT Picower Institute McGovern Institute MIT Brain and Cognitive Sciences

You can identify the middle (input) layer of the cortex by locating the crossover between gamma and alpha/beta power. It's common in the cortex and likely has significant functional relevance. Laminar Dynamics of Target Selection in the PPC jneurosci.org/content/44/21/… #neuroscience

A great showcase of distinguishing superficial vs deep cortical layers with spectrolaminar motif to identify layer-specific effects (Janahan Selvanayagam et al). Laminar ephys adds a new dimension to existing datasets! jneurosci.org/content/44/21/…

This note from the 1st recipient of our new scholarship brought a tear to my eye. The Earl K. Miller First Generation Scholarship is given to 1st generation college students at Kent State University. You can contribute. Contact: kent.edu/philanthropy Kent State

New results! Anterior cingulate neurons display subregion-specific interaction with frontal eye fields as revealed by combined antidromic stimulation and resting state imaging biorxiv.org/content/10.110… #neuroscience

Here is our response to Mackey, Schroeder, et al. and their comments on our Nature Neuroscience paper on the spectrolaminar motif. We re-affirm the motif's ubiquity and demonstrate its presence in their data and other independent datasets from Saalmann and Chandrasekaran Labs.